School of Medicine:
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Here at the Duke Human Vaccine Institute (DHVI), we value collaborations, and pride ourselves in providing an excellent environment for academic and professional growth. This position will lead and execute major projects within the DHVI Viral Genetics Core under the leadership of Dr. Wilton Williams with a focus on understanding the Non Human Primate (NHP) immune system genome. The results from these studies will identify host and genetic factors that govern vaccine development, including roadblocks towards an effective HIV-1 vaccine that may be circumvented with novel strategies. The applicant will have experience in analyzing genomes and transcriptomes generated using sequencing platforms such as Illumina and PACBIO. Defining primate and NHP immunity at baseline and following viral infection or vaccinations is an area of HIV research that is understudied. Thus, the ability to design to design experiments to address this area of research is desired.RESPONSIBILITIES:
- Independently lead and execute major and complex scientific projects within the Williams laboratory, serve as the point person for assigned projects and coordinate collaborative science among investigators within DHVI and externally to effectively meet the scientific milestones and project deadlines. Design experiments to address primate and NHP immunity using next generation deep-sequencing platformsAnalyze genomes and transcriptomes generated by next generation deep-sequencing platforms Computational analysis of large immunoglobulin gene sequence data setsDesign and execute experiments; analyze and interpret data; archive experiments in a manner that is scientifically justifiable, reliable and understandable to others; and provide guidance and oversight to junior scientists.Develop and optimize new assays for the laboratory
- Train laboratory staff and DHVI trainees
- Accurately document detailed research experiments in a laboratory notebookPerform other related duties as necessary and requested
EDUCATION, SKILLS, & EXPERIENCE REQUIREMENTS
- A Ph.D or equivalent doctorate in biological science, chemistry, or related field is required.
- Biological science laboratory experiences with knowledge of the immune system genome, including sequencing genomes and transcriptomes of immune cells.
- A basic level of understanding the analysis of deep-sequencing data is desired in order to facilitate an effective collaboration with our computational biology team at the DHVI.
- Excellent oral and written communication skills
- Must be team oriented and able to work effectively in a highly collaborative work environment
- Must be able to manage multiple and rapidly changing priorities and have the ability to learn and apply new skills and concepts
- Must be detail-oriented and well-organized
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