Postdoctoral Associate (Sylvester Comprehensive Cancer Center)

Job description

Job location: Miami, FL

Employment Type: Full-time
Posted data: 2020-08-28
Req: R100041371
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Transforming Lives

The University of Miami is among the top research universities and academic medical centers in the nation, and one of the largest private employers in South Florida.

With more than 16,000 faculty and staff, the University strives for excellence, and is driven by a powerful mission to transform and impact the lives of its students, patients, members of the community, and people across the globe.

The University is committed to fostering a culture of belonging, where everyone feels valued and has the opportunity to add value. Through values of Diversity, Integrity, Responsibility, Excellence, Compassion, Creativity, and Teamwork (DIRECCT) the U community works together to create an environment driven by purpose, excellence, community, and service.

About This Position

A postdoctoral fellow position is available in Dr. Morey’s lab at Sylvester Comprehensive Cancer

Center, University of Miami Miller School of Medicine. The Morey lab focuses on the epigenetic

mechanisms that control cancer initiation and progression, and stem cell differentiation.

Previous work in our lab have shown that the architecture of Polycomb-group (PcG) complexes

is instrumental in regulating stem cell fate decisions (Morey et al. Cell Stem Cell, 2012; Morey et

al. Cell Reports, 2013; Morey et al. Cell Stem Cell, 2015). Recently, we have discovered that PcG

complexes are recruited to active enhancers in multiple cancers, highlighting an under-explored

function of PcG complexes in regulating oncogenic transcriptional programs in cancer (Chan et

al. Nature Comm, 2018; Chan and Morey, Trends in Biochemical Sciences, 2019; Zhang et al.

Science Advances, 2020).

Our research program aims to characterize the PcG-mediated mechanisms in multiple cancer

types, including breast cancer, and in human pluripotent stem cell differentiation. The projects

will employ genetic, biochemical and genomic approaches including 3D chromatin architecture

assays (HiC and HiChIP) and CRISPR/Cas9 screens, as well as standard genome-wide assays (ChIPRNA-

ATAC-seq). Experiments will be performed using both cell culture (cancer cells and human

embryonic stem cells) and in vivo models (xenografts and PDX models).

Minimum Qualifications

Successful candidates will have earned a Ph.D. in genetics, molecular biology, cellular biology, or

related fields and demonstrated the ability to complete research projects independently.

Expertise in epigenetics in any model system will greatly strengthen the application. Experience

with computational analysis of genomic data is a plus but is not required. Skill in collecting, organizing, and analyzing data. Ability to recognize, analyze, and solve a variety of problems. Ability to exercise sound judgment in making critical decisions.

The University of Miami offers competitive salaries and a comprehensive benefits package including medical, dental, tuition remission and more.

UHealth-University of Miami Health System, South Florida's only university-based health system, provides leading-edge patient care powered by the ground breaking research and medical education at the Miller School of Medicine. As an academic medical center, we are proud to serve South Florida, Latin America and the Caribbean. Our physicians represent more than 100 specialties and sub-specialties, and have more than one million patient encounters each year. Our tradition of excellence has earned worldwide recognition for outstanding teaching, research and patient care. We're the challenge you've been looking for.

Patient safety is a top priority. As a result, during the Influenza ("the flu") season (September through April), the University Of Miami Miller School Of Medicine requires all employees who provide ongoing services to patients, work in a location (all Hospitals and clinics) where patient care is provided, or work in patient care or clinical care areas, to have an annual influenza vaccination. Failure to meet this requirement will result in rescinding or termination of employment.

The University of Miami is an Equal Opportunity Employer - Females/Minorities/Protected Veterans/Individuals with Disabilities are encouraged to apply. Applicants and employees are protected from discrimination based on certain categories protected by Federal law. Click here for additional information.

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Job No:
Posted: 8/29/2020
Application Due: 11/27/2020
Work Type: