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Postdoctoral Fellow - Integrative Biology Laboratory, Dr. Graham McVicker

Job Details

The McVicker laboratory studies how human genetic variation affects gene regulation by combining experimental approaches with computational analyses. We are especially interested in identifying pathogenic regulatory variants that act in immune cells and cancer cells. Currently, we are developing new tools to discover somatic regulatory mutations in cancer genomes, and manipulating cell lines with high-throughput CRISPR technologies to discover new regulatory sequences. In much of our research, we develop sophisticated computational and statistical methods so that we can extract subtle signals from noisy experimental data.

Position Description: 

Quantitative trait mapping of single cell gene expression and chromatin traits
The McVicker Laboratory at the Salk Institute for Biological Studies is seeking a postdoctoral fellow to tackle cutting-edge research problems in genetics, gene regulation and chromatin biology. The successful candidate will develop new statistical and computational methods to map single cell gene expression and chromatin traits and will have the opportunity analyze large single-cell ATAC-seq and single-cell RNA-seq datasets. These datasets are being collected by our collaborators at UCSD, and will be used to better understand the genetic basis of complex diseases including opioid addiction and type 1 diabetes.

We are committed to diversity in science. The Salk Institute for Biological Studies is an Equal Opportunity Employer.

The Salk Institute for Biological Studies is an architectural landmark and is one of the top biological research institutes in the world. It is located in beautiful La Jolla, a community of San Diego, California, and is close to many biotechnology companies and other research institutes including the University of California, San Diego.


Applicants should have a strong quantitative background and must have, or expect to receive, a Ph.D. in a relevant discipline (Genetics, Computer Science, Statistics, Bioinformatics, etc.).


Required skills/experience:

  • Experience with Python or other scripting language
  • Experience in R or other data analysis language
  • Experience in statistics and/or machine learning
  • Proficiency in Unix / Linux
  • Proficiency in scientific writing and communication
  • Contributions to published papers/preprints
  • Strong interest in biology, chromatin, and gene regulation

Desired skills/experience:

  • Experience with bioinformatics tools / software
  • Experience with next-generation sequencing data
  • Experience with single-cell genomics
  • Experience with C/C++ or other compiled programming language
  • Ability to work closely with collaborators from diverse backgrounds
  • Interest in complex human traits, especially diabetes or addiction, using human samples and animal models of disease

Application Instructions: 

Email Dr. Graham McVicker at with your CV, a brief cover letter describing your background and research interests, and contact information for 2-3 references.




Working at Salk Institute for Biological Studies

The Salk Institute for Biological Studies is one of the world's preeminent basic research institutions, where internationally renowned faculty probe fundamental life science questions in a unique, collaborative, and creative environment. Focused on both discovery and mentoring future generations of researchers, Salk scientists make groundbreaking contributions to our understanding of cancer, aging, Alzheimer's, diabetes, and cardiovascular disorders by studying neuroscience, genetics, cell and plant biology, and related disciplines.

Faculty achievements have been recognized with numerous honors, including Nobel Prizes and memberships in the National Academy of Sciences. Founded in 1960 by polio vaccine pioneer Jonas Salk, M.D., the Institute is an independent nonprofit organization and architectural landmark.

Salk Equal Opportunity and Non-Discrimination Statement

The Salk Institute for Biological Studies is committed to providing equal access to opportunities for students, employees, applicants for employment and other persons.

Our policies prohibit harassment or unlawful discrimination against individuals on the basis of sex, gender, marital or parental status, pregnancy, childbirth, breastfeeding, medical conditions/disabilities related to pregnancy, childbirth or breastfeeding, gender identity, gender expression, or sexual orientation age, ancestry, color, religion (including religious dress and grooming practices), family and/or medical care leave status, disability (mental or physical), registered domestic partner status, legally protected medical condition, genetic information, military or veteran status (disabled veteran, veteran of the Vietnam era, other covered veteran status), national origin (including language use restrictions and possession of a driver’s license), race, religion or any other classification protected by local, state or federal laws.

The Salk Institute participates in the E-Verify program.

Reasonable accommodation is available for qualified individuals with disabilities and for individuals with religious restrictions.

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