Senior Research Fellow

Employer
University of Massachusetts Amherst
Location
UMass Amherst

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Faculty Jobs
Science & Technology, Chemistry & Biochemistry

Job Details

Job no: 505784
Work type: Senior/Research Fellow (Amherst Only)
Location: UMass Amherst
Department: Biology
Union: Non-Unit Exempt
Categories: Laboratory & Research

About UMass Amherst

UMass Amherst, the Commonwealth's flagship campus, is a nationally ranked public research university offering a full range of undergraduate, graduate and professional degrees. The University sits on nearly 1,450-acres in the scenic Pioneer Valley of Western Massachusetts, and offers a rich cultural environment in a bucolic setting close to major urban centers. In addition, the University is part of the Five Colleges (including Amherst College, Hampshire College, Mount Holyoke College, and Smith College), which adds to the intellectual energy of the region.

Job Summary

The Stephens Lab (https://www.bio.umass.edu/biology/stephens/home) at the University of Massachusetts Amherst is recruiting a Senior Research Fellow. The Stephens lab is a new lab and studies the mechanical and shape properties of the cell nucleus and how these properties affect major nuclear functions such as genome organization, DNA damage, compartmentalization, and transcription. Abnormal nuclear shape has been used as diagnostic and prognostic marker for human disease such as cancer for nearly a century without understanding how these nuclear abnormal deformations occur and what their real consequences are to cell function.

The responsibilities of the Senior Research Fellow include working closely with the PI to establish mechanisms quantitatively measuring force response and nuclear morphology in an automated fashion. One goal will be to write a new program in LabView or Python to track micropipette tips and nucleus deformation to measure force response of nuclei under micromanipulation. The second goal will be to generate a machine learning algorithm for segmenting and measuring nuclei, with the capacity to discern normally and abnormally shaped nuclei. It is essential that the Senior Research Fellow be well-versed in microscopy and image analysis for both of the major goals. The Senior Research Fellow will then use these tools to perform experiments on cells using micromanipulation and microscopy to discern the mechanical role of chromatin in the nucleus and how it affects major nuclear functions.

Essential Functions

Examples of duties:

  • Develop a new analysis program for tracking micropipette tips and nuclei strain during micromanipulation (preferably in LabView or Python)
  • Develop a pipeline for automated microscope image segmentation of nuclei using various available machine learning algorithms
  • Preparation of cells for imaging
  • Microscopy imaging and image analysis of cell samples on a daily basis
  • Secondary role in maintaining cell cultures in conjunction with the Lab Manager
  • Other Functions

  • Work collaboratively and effectively to promote teamwork, diversity, equality and inclusiveness.
  • Work in partnership with colleagues within the CNS community and across the campus to support the Dean’s strategic priorities.
  • Perform other duties as assigned in support of the mission and goals of the College of Natural Sciences.
  • Minimum Qualifications (Knowledge, Skills, Abilities, Education, Experience, Certifications, Licensure)

  • PhD in Biology or related field.
  • At least 5 years of post doc experience.
  • Preferred Qualifications (Knowledge, Skills, Abilities, Education, Experience, Certifications, Licensure)

  • Coding in Python (or other languages).
  • Well-versed in microscopy imaging and analysis.
  • Knowledge of cell culture.
  • Molecular Biology skills (DNA/RNA purification, Western blots, Immunofluorescence).
  • Educated in Physics and/or Engineering.
  • Physical Demands/Working Conditions

    • Typical lab environment.

    Additional Details

    • This position is for one year with the potential of a reappointment depending on job performance and available funding.

    Work Schedule

    • Monday - Friday, 8:30am - 5:00pm.
    • Hours may vary.

    Salary Information

    Salary will commensurate with experience.

    Special Instructions to Applicants

    Submit a letter of application, resume and contact information for three professional references. Apply by July 17, 2020 in order to ensure priority consideration. Search may remain open until a suitable candidate pool has been identified.

    As part of a commitment to their own multicultural community, CNS seeks an individual with a demonstrated commitment to diversity and one who will understand and embrace university initiatives and aspirations. (https://www.cns.umass.edu/diversity-equity-inclusion)

    UMass Amherst is committed to a policy of equal opportunity without regard to race, color, religion, gender, gender identity or expression, age, sexual orientation, national origin, ancestry, disability, military status, or genetic information in employment, admission to and participation in academic programs, activities, and services, and the selection of vendors who provide services or products to the University. To fulfill that policy, UMass Amherst is further committed to a program of affirmative action to eliminate or mitigate artificial barriers and to increase opportunities for the recruitment and advancement of qualified minorities, women, persons with disabilities, and covered veterans. It is the policy of the UMass Amherst to comply with the applicable federal and state statutes, rules, and regulations concerning equal opportunity and affirmative action.

    Advertised: Jul 8 2020 Eastern Daylight Time
    Applications close:

    Organization

    The University of Massachusetts Amherst is one of the preeminent public research universities in America. Nestled in idyllic Amherst, Massachusetts—often called “The top college town in North America”—the campus is consistently ranked among the top public research universities in the nation, and offers a rich cultural environment in a rural setting close to major urban centers. 

    As one of the nation's top public research universities – as measured by national and international rankings, academic citations, and research funding – the campus spends more than $180 million on research each year, demonstrating its contribution to the nation’s position as a technological and economic leader. The university works in conjunction with academic, government, and private partners to translate new knowledge and scientific discoveries into technical innovations and scholarly works that create opportunities for students, faculty and the public. 

    Eight schools and colleges offer more than 85 undergraduate majors, 68 master’s and 48 doctoral degree programs, many counted among the top programs in the nation and world. UMass Amherst is also home to New England's premier honors college.

    The 1,159 full-time faculty members are dedicated teachers and world-renowned researchers and the campus has regularly been listed among the top performers in terms of faculty awards. With over 24,000 students from all 50 states and over 70 countries, the student body is the most academically successful in the history of the campus. Students participate in 240 organizations, 21 NCAA Division I athletic teams, extensive intramurals, living-learning residence halls, community service, and internships. With one of the largest residential life systems in the nation, UMass Amherst houses approximately 12,000 students on campus. The university is enjoying a facilities renaissance, including new buildings in the sciences, the arts, and recreation. UMass Amherst is part of the Five College consortium with Smith, Mount Holyoke, Hampshire and Amherst colleges.

    As an employer, the University of Massachusetts Amherst is a national leader in developing family-friendly policies, benefits and amenities designed to help faculty members develop both productive careers and satisfying personal lives. The university offers one of the nation’s most generous parental leave policies. The university is also part of the Academic Career Network, a regional consortium formed to serve dual-career couples and encourage greater diversity in the academy.

     

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    Telephone
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    Location
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    Whitmore Administration Building
    Amherst
    Massachusetts
    01003
    United States

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