Post Doctoral Associate
A postdoctoral research position is available in the laboratory of Michael Lodato, Ph.D. to work on a new project using cutting-edge single-cell whole-genome sequencing approaches to study DNA damage and subsequent somatic mutations in the human brain. Our previous work has shown that human neurons contain hundreds to thousands of somatic point mutations per genome (Lodato et al., Science, 2015, PMID: 26430121; Lodato et al., Science 2018, PMID: 29217584). This project will focus on testing a new hypothesis about neurodegenerative diseases, namely that damage to neuronal genomes is a critical downstream effector of neuron death, potentially having a major impact on our understanding of these diseases. Our study will be at the interface of basic science and translational medicine, using new molecular biology techniques in human patient samples. The best candidates will have a desire to work in a new lab in a new and exciting field of research, and have experience in molecular biology, particularly with high-throughput sequencing. Previous bioinformatic experience is a plus but not required.
Our brand-new lab is part of the Department of Molecular, Cell and Cancer Biology at the University of Massachusetts Medical School (UMMS) in Worcester, MA, giving us access to a multitude of core facilities, shared equipment, and a highly stimulating and interactive intellectual environment. UMMS is a vibrant and exciting research community, with ~3,000 faculty, including ~320 basic science principal investigators and ~2,500 clinical faculty. The UMMS faculty includes members of the National Academy of Sciences, the Howard Hughes Medical Institute, and the American Academy of Arts and Sciences. UMMS faculty have won several major awards, including the Keck Award, the Lasker Prize, and the Nobel Prize in Physiology or Medicine, among others.