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Postdoctoral Position in Tumor Metabolism and Circadian Clock Disruption

Employer
University of California-Irvine
Location
Irvine

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Position Type
Postdoc
Employment Type
Full Time
Institution Type
Four-Year Institution

Job Details



University of California, Irvine

Postdoctoral Position in Tumor Metabolism and Circadian Clock Disruption


Recruitment Period
Open May 3rd, 2019 through Wednesday, Jul 31, 2019 at 11:59pm (Pacific Time) Description

Postdoctoral Position in Tumor Metabolism and Circadian Clock Disruption

A postdoctoral position is immediately available within the Masri Lab at the University of California, Irvine (UC Irvine). The Masri lab employs a systemic approach to understanding tumor metabolism that is linked to the circadian clock, the biological pacemaker that regulates diurnal physiology. We are interested in two research questions. The first question relates to how genetic disruption of the circadian clock in mouse models alters tumorigenesis both at the level of initiation and disease progression. The second question is aimed at elucidating the systemic crosstalk between tumors and peripheral tissues and how cancer cells are able to rewire circadian metabolism at a distance.

We are seeking independent and motivated postdoctoral candidates interested in a multi-disciplinary approach to tumorigenesis. We are particularly focused on tumor metabolism, circadian clock disruption, and stem cell biology, with an emphasis on transcriptional and epigenetic control mechanisms. The Masri lab utilizes genetic mouse models, molecular and cell biology, as well as genome-wide ‘omics' approaches to determine changes in gene expression programs, histone modifications, and alterations in metabolites using metabolomics. In addition, bioinformatics expertise is an advantage, but certainly not required. Experience with mouse handling and experiments, mammalian cell culture, and routine molecular and cell biology are needed, and at least 1 first author publication from the Ph.D. training period is required.

For more details about the Masri Lab, including relevant publications (Cell, 2014; Cell, 2016; PNAS, 2013; Science Signaling, 2014; Nature Neuroscience, 2010) please visit our website at:
https://masrilaboratory.com/
https://www.faculty.uci.edu/profile.cfm?faculty_id=6387

The Masri Lab is part of the Department of Biological Chemistry, Chao Family Comprehensive Cancer Center, and the Center for Epigenetics and Metabolism at UC Irvine. We are located in Southern California, between Los Angeles and San Diego. For further details about UC Irvine and Southern California, please see: https://uci.edu/

Additional information regarding the position can be obtained by contacting:

Professor Selma Masri
Masrilaboratory@gmail.com

To Apply: Interested candidates should apply through UC Irvine's RECRUIT system located at: https://recruit.ap.uci.edu/apply/JPF05289.

Each application must contain the following items:

  • Brief statement of research interests and future goals
  • CV detailing research experience, publications, any fellowships obtained during the training period, and other relevant information
  • List of any manuscripts in preparation or currently under review
  • Names of 3 references that are familiar with the research experience of the candidate and can provide letters of recommendation upon request

    The University of California, Irvine is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy.


    To apply, visit https://recruit.ap.uci.edu/JPF05289





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  • Organization

    Founded in 1965, UC Irvine combines the strengths of a major research university with the bounty of an incomparable Southern California location. Over five remarkable decades, UCI has become internationally recognized for efforts that are improving lives through research and discovery, fostering excellence in scholarship and teaching, and engaging and enriching the community.UC student center

    With more than 33,000 students, 1,200 faculty members and 10,000 staff, UCI is among the fastest-growing campuses in the University of California system. Increasingly a first-choice campus for students, UCI ranks among the top U.S. universities in the number of undergraduate applications and continues to admit freshmen with highly competitive academic profiles. Orange County’s second-largest employer, UCI generates an annual economic impact on the county of $5 billion.

    UCI is a center for quality education that honors classic instruction while incorporating the best new scholarship. U.S. News & World Report consistently ranks UCI among the nation’s best universities. Achievements in the sciences, social sciences, social ecology, arts, humanities, medicine and business also have garnered numerous national rankings for UCI’s schools, departments and programs. Three UCI researchers have won Nobel Prizes – most recently Irwin Rose, in chemistry, in 2004.

    Interdisciplinary research, a UCI hallmark, is evident in the California Institute for Telecommunications and Information Technology, or Calit2, Newkirk Center for Science and Society, Center for the Study of Democracy, Institute of Transportation Studies, Institute for Genomics and Bioinformatics, and innovative instructional programs in biomedical engineering, international studies, global cultures, arts and technology, and other collaborations.

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    UCI reaches beyond the classroom and laboratory to help solve societal issues and support human development. In the health sciences, UCI is noted for its research on cancer, the neurosciences and the genetic underpinnings of disease. UCI Medical Center, Orange County’s only university hospital and Level I trauma center, has been ranked among the nation’s best hospitals by U.S. News & World Report for 16 consecutive years.

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    The university is also addressing the needs of the community and growing world population in an environmentally sustainable way. From the development of new and reliable processes for electricity and alternative fuels to critical water and waste management solutions, UCI consistently tops the list in Sierra magazine’s “Coolest Schools” report, its annual sustainability ranking of U.S. colleges and universities.  

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    UCI is benefiting the community and the world in countless ways through its scholarly, scientific, creative and economic contributions. On its way to becoming a flagship UC campus and one of the nation’s very best universities, UCI has embarked on a strategic plan that will ensure the campus continues to inspire excellence as it fulfills its research, teaching and public service missions in the decades ahead.

    Company info
    Website
    Telephone
    949-824-5011
    Location
    University of California, Irvine
    Irvine
    CA
    92697
    US

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