Postdoctoral Position in Tumor Metabolism and Circadian Clock Disruption

Job description



University of California, Irvine

Postdoctoral Position in Tumor Metabolism and Circadian Clock Disruption


Recruitment Period
Open May 3rd, 2019 through Wednesday, Jul 31, 2019 at 11:59pm (Pacific Time) Description

Postdoctoral Position in Tumor Metabolism and Circadian Clock Disruption

A postdoctoral position is immediately available within the Masri Lab at the University of California, Irvine (UC Irvine). The Masri lab employs a systemic approach to understanding tumor metabolism that is linked to the circadian clock, the biological pacemaker that regulates diurnal physiology. We are interested in two research questions. The first question relates to how genetic disruption of the circadian clock in mouse models alters tumorigenesis both at the level of initiation and disease progression. The second question is aimed at elucidating the systemic crosstalk between tumors and peripheral tissues and how cancer cells are able to rewire circadian metabolism at a distance.

We are seeking independent and motivated postdoctoral candidates interested in a multi-disciplinary approach to tumorigenesis. We are particularly focused on tumor metabolism, circadian clock disruption, and stem cell biology, with an emphasis on transcriptional and epigenetic control mechanisms. The Masri lab utilizes genetic mouse models, molecular and cell biology, as well as genome-wide ‘omics' approaches to determine changes in gene expression programs, histone modifications, and alterations in metabolites using metabolomics. In addition, bioinformatics expertise is an advantage, but certainly not required. Experience with mouse handling and experiments, mammalian cell culture, and routine molecular and cell biology are needed, and at least 1 first author publication from the Ph.D. training period is required.

For more details about the Masri Lab, including relevant publications (Cell, 2014; Cell, 2016; PNAS, 2013; Science Signaling, 2014; Nature Neuroscience, 2010) please visit our website at:
https://masrilaboratory.com/
https://www.faculty.uci.edu/profile.cfm?faculty_id=6387

The Masri Lab is part of the Department of Biological Chemistry, Chao Family Comprehensive Cancer Center, and the Center for Epigenetics and Metabolism at UC Irvine. We are located in Southern California, between Los Angeles and San Diego. For further details about UC Irvine and Southern California, please see: https://uci.edu/

Additional information regarding the position can be obtained by contacting:

Professor Selma Masri
[email protected]

To Apply: Interested candidates should apply through UC Irvine's RECRUIT system located at: https://recruit.ap.uci.edu/apply/JPF05289.

Each application must contain the following items:

  • Brief statement of research interests and future goals
  • CV detailing research experience, publications, any fellowships obtained during the training period, and other relevant information
  • List of any manuscripts in preparation or currently under review
  • Names of 3 references that are familiar with the research experience of the candidate and can provide letters of recommendation upon request

    The University of California, Irvine is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy.


    To apply, visit https://recruit.ap.uci.edu/JPF05289





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    Job No:
    Posted: 7/15/2019
    Application Due: 8/1/2019
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