Job location: Charlottesville, VA
Employment Type: Full-time
Posted data: 2019-04-25
The Adli lab in the Department of Biochemistry & Molecular Genetics at the University of Virginia is seeking a Laboratory Specialist to use basic molecular biology tools as well as CRISPR technology to assist ongoing research projects in the lab. The candidate may also help to maintain laboratory space, equipments and servers as well as process purchases for the lab. In this role, the candidate will particularly help senior members of the lab to design, and clone CRISPR sgRNA constructs. Previous molecular cloning experience is highly desired and recommended. In this role, she/he will also help with the analysis and interpretation of high-throughput genomic data.
The Adli lab (www.adlilab.org) is using genomic and epigenomic mapping, manipulating as well as imaging approaches to understand how external (developmental and environmental cues) and internal (genetic abnormalities) cues alter gene regulation, chromatin structure, and the 3D genome organization in the nuclear space. In addition to using conventional genomic and epigenomic approaches, the lab is also exploiting its existing expertise in CRISPR technology (Nature Biotechnology, 2014; NAR, 2015) to develop and use CRISPR-based next-generation locus specific chromatin manipulation and imaging (Nature Communications, 2017) as well as catalytically inactive Cas9 based gene silencing through base editing (Nature Methods, 2016; Nature Methods, 2017) technologies. The current proposal is based on our recent exciting preliminary results and long-term interest in understanding the role of nuclear lamina and its associated proteins in genome architecture and gene regulation.
Please attach a cover letter, curriculum vitae, and contact information for three references to your application. Incomplete applications will not receive full consideration.
This is a restricted position contingent upon the continuation of funding.
- Specialize in lab and/or other research methods and equipment functions specific to Principal Investigators and/or labs. Demonstrate expertise in troubleshooting problems and recommending solutions. Perform a variety of tests requiring high degree of proficiency.
- Assist in evaluation of research methods, procedures, and techniques based on established objectives.
- May perform small animal surgery.
- Provide basic assistance to researchers in manipulating, computing, and analyzing data using specialized statistical computer software. Evaluate experiment results using statistical and multivariate analyses. Research, compile, and maintain complex statistical, numerical, and computerized reports.
- Perform library and literature research.
- Assist in instructing lab academic sections in lab methods, procedures, and safety.
- Explain work instructions and may adapt general methods and procedures in order to meet the needs of the research.
- Assist in training other staff members on procedures.
In addition to the above job responsibilities, other duties may be assigned.
Education: Bachelor's degree by start date
Experience: At least three years of experience, which may include experience gained while a student.
This position can spend extensive periods of time standing and squatting while conducting experiments or caring for animals. Also requires keyboarding and other bench work and animal procedures requiring finer finger manipulation.The University of Virginia, including the UVA Health System and the University Physician’s Group are fundamentally committed to the diversity of our faculty and staff. We believe diversity is excellence expressing itself through every person's perspectives and lived experiences. We are equal opportunity and affirmative action employers. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender identity, marital status, national or ethnic origin, political affiliation, race, religion, sex (including pregnancy), sexual orientation, veteran status, and family medical or genetic information.