Laboratory and Research Technician 2
Job location: Charlottesville, VA
Employment Type: Full-time
Posted data: 2019-04-25
The Department of Pathology, at the University of Virginia School of Medicine, seeks a Laboratory and Research Technician 2 to work in the laboratory of Dr. Chance John Luckey, MD, PhD. We are looking for a talented and self-motivated individual who is interested in joining a growing team focused on understanding the molecular regulation of immune memory, with a specific focus on understanding the immune responses to transfused red cells in both mice and patients. This position is ideal for recent science graduates who are interested in gaining the scientific skills and publications that are essential for successful application to science PhD graduate programs, MD/PHD physician scientist programs and medical school.
A key feature of our immune response is its ability to remember previous exposures and respond more rapidly upon re-challenge. While memory immune responses serve as the basis for successful vaccination, in certain settings they can also be pathogenic. One clinically important setting is red blood cell (RBC) alloimmunization, where re-exposure to allogeneic RBCs can lead to potentially life threatening hemolytic reactions as well as hemolytic disease of the fetus and newborn (Luckey and Silberstein Blood 2013). Our lab has recently identified for the first time a specific molecule (IL-6Rα), its downstream cellular target (CD4+ T cells) and resultant functional outcome (TFH differentiation) that drives RBC alloimmunization (Arneja et al Haematologica 2016). This position will expand on our current work aimed at uncovering the molecular and cellular regulators of RBC alloimmunization in mice, and further determine whether these regulators also function in key high-risk patient populations.
Qualified applicants must have either i) a bachelor’s degree in related science or ii) an associate’s degree and at least 2 years of lab experience which may include student experience. Comfort with learning how to work with experimental mouse models is a must, and experience with mouse models a strong plus. The candidate will investigate the basic immunology driving alloimmunization to transfused red cells and combine recently developed transgenic mouse models of red blood alloimmunization with pre-existing genetic gain- and loss- of function mouse models to elucidate the cell and molecular control of RBC alloimmune responses in vivo. Candidates are expected to rapidly progress to be able to carry out high level, complex research experiments under the general direction of the principal investigator. Candidates with experience with in vivo cellular and molecular immunology, human immunology, multi-color flow cytometry, or signaling assays are preferred.
The University of Virginia is located in beautiful Charlottesville Virginia, a vibrant University town nestled in the foothills of the blue ridge mountains and Shenandoah National Park. Charlottesville is consistently voted as one of the happiest and best places to live in the USA, and the University of Virginia Medical Center and the Luckey Lab provides a strong yet supportive scientific environment in which to further your scientific career.
This position is restricted and contingent upon the continuation of funding.
The position will remain open until filled.
For further information about the position, please contact Chance John Luckey, MD, via email at [email protected]
For questions regarding the application process, please contact Mary White via email at [email protected] or telephone at 434-924-9712.
EXTERNAL APPLICANTS: please apply through Workday at the following URL, https://uva.wd1.myworkdayjobs.com/UVAJobs , and search for requisition # R0005589. Complete an application online and attach CV or resume, and contact information for three references (name. email address, telephone number, address).
INTERNAL UVA APPLICANTS: please apply through your Workday Home page, search “Find Jobs”, and search for requisition #ROOO5589. Complete an application online and attach a cover letter, CV/resume, and contact information for three references (name, email address, telephone number, address).
Lab and Research Technician 2 employees provide increasingly complex technical support for projects and may engage in increasingly complex scientific experiments. May handle more sophisticated administrative and logistical tasks. Lab and Research Technician 2 employees operate under supervision with a degree of independence when following set protocols and procedures. Responsibilities can include:
- Perform similar duties to the Technician 1, such as performing analyses, participating in research or clinical work involving treatment operations and experiments with animals to include care and feeding, cage cleaning and sanitization, and observation during post-operative or treatment periods, and maintaining equipment and apparatuses.
- Coordinate and participate in a variety of routine technical duties by providing assistance to clinical and research staff in testing, determinations, and experiments.
- Assist in evaluating research methods, procedures, and techniques, based on established objectives.
- Provide basic assistance to researchers in manipulating, computing, and analyzing data using specialized statistical computer software.
- May perform certain surgical procedures on small lab animals.
- Assist with training other staff members on procedures; may supervise students or volunteers.
- Assist Principal Investigators and senior staff in developing new strategies and techniques for experimentation.
- Technician 2 employees in Social Sciences and Humanities will provide routine, technical, and administrative support to research projects.
- May contact and coordinate schedules with study subjects, handle information intake, and record and track results.
- In addition to the above job responsibilities, other duties may be assigned.
Education: Qualified applicants must have either i) a bachelor’s degree in related science or ii) an associate’s degree and at least 2 years of lab experience which may include student experience. Bachelor's degree is preferred.
Experience: At least 2 years of lab experience which may include student experience. Bachelor's degree in related science will be considered in lieu of experience. Comfort with learning how to work with experimental mouse models is a must, and experience with mouse models a strong plus. Candidates are expected to rapidly progress to be able to carry out high level, complex research experiments under the general direction of the principal investigator. Candidates with experience with in vivo cellular and molecular immunology, human immunology, multi-color flow cytometry, or signaling assays are preferred.
This position can spend extensive periods of time standing and squatting while conducting experiments or caring for animals. Also requires keyboarding and other bench work and animal procedures requiring finer finger manipulation.The University of Virginia, including the UVA Health System and the University Physician’s Group are fundamentally committed to the diversity of our faculty and staff. We believe diversity is excellence expressing itself through every person's perspectives and lived experiences. We are equal opportunity and affirmative action employers. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender identity, marital status, national or ethnic origin, political affiliation, race, religion, sex (including pregnancy), sexual orientation, veteran status, and family medical or genetic information.