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Postdoctoral Scholar for Epigenomic Mechanisms of Memory Disruption by Early-life Seizures

Employer
University of California-Irvine
Location
Irvine

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Position Type
Postdoc
Employment Type
Full Time
Institution Type
Four-Year Institution

Job Details



University of California, Irvine

Postdoctoral Scholar for Epigenomic Mechanisms of Memory Disruption by Early-life Seizures


Recruitment Period Open February 14th, 2019 through June 30th, 2019 Description

A postdoctoral position is offered in a vibrant Neuroscience laboratory to probe the transcriptional and epigenetic mechanisms initiated by early-life seizures that differentially program newborn and mature hippocampal dentate gyrus granule cells and pyramidal neurons. These changes cause significant disruption of hippocampus-dependent memory processes associated with Epilepsy, with major clinical importance.

The NIH-funded project will employ innovative methodologies to examine, at single cell resolution, the role of specific transcription factors in functional and structural hippocampal derangements that promote memory problems. ChIP-seq, single-cell RNA-seq and subsequent interventional approaches will be employed. Additional methods used in the lab include DREADD technology, live 2-photon imaging, as well as DTI imaging and behavioral testing.

(See: Patterson et al., J Neurosci, 2017;, McClelland et al., eLife 2014; Singh-Taylor et al., Molec Psych 2018; Bolton et al., Biol Psych 2018; Dube et al., Trends Neurosci, 2007).

The culturally diverse and welcoming laboratory is located on the UC Irvine campus, a rich community of Molecular and Neuroscience research within Southern California.

Candidates should have a recent PhD degree and experience in Molecular Biology, and must be highly motivated. Experience in Bioinformatics and Neuroscience is desirable.

To Apply, please visit:
https://recruit.ap.uci.edu/JPF05170

Please upload a CV, a brief statement of research accomplishments and interests, and a list of references.

Thank you,
Tallie Z. Baram, MD, PhD
D.D. Shepard Professor of Neurological Sciences
Prof. Pediatrics, Anatomy/ Neurobiology, Neurology
University of California-Irvine, CA, USA

The University of California, Irvine is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy.



To apply, visit https://recruit.ap.uci.edu/JPF05170





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Organization

Founded in 1965, UC Irvine combines the strengths of a major research university with the bounty of an incomparable Southern California location. Over five remarkable decades, UCI has become internationally recognized for efforts that are improving lives through research and discovery, fostering excellence in scholarship and teaching, and engaging and enriching the community.UC student center

With more than 33,000 students, 1,200 faculty members and 10,000 staff, UCI is among the fastest-growing campuses in the University of California system. Increasingly a first-choice campus for students, UCI ranks among the top U.S. universities in the number of undergraduate applications and continues to admit freshmen with highly competitive academic profiles. Orange County’s second-largest employer, UCI generates an annual economic impact on the county of $5 billion.

UCI is a center for quality education that honors classic instruction while incorporating the best new scholarship. U.S. News & World Report consistently ranks UCI among the nation’s best universities. Achievements in the sciences, social sciences, social ecology, arts, humanities, medicine and business also have garnered numerous national rankings for UCI’s schools, departments and programs. Three UCI researchers have won Nobel Prizes – most recently Irwin Rose, in chemistry, in 2004.

Interdisciplinary research, a UCI hallmark, is evident in the California Institute for Telecommunications and Information Technology, or Calit2, Newkirk Center for Science and Society, Center for the Study of Democracy, Institute of Transportation Studies, Institute for Genomics and Bioinformatics, and innovative instructional programs in biomedical engineering, international studies, global cultures, arts and technology, and other collaborations.

The university is dedicated to excellence through diversity and to the goal of reflecting equity and inclusion in our faculty, staff and student populations. Faculty and staff diversity affinity groups foster cross-departmental social interaction, professional networking, cultural competencies, recruiting and mentoring.

Committed to the Community

UCI reaches beyond the classroom and laboratory to help solve societal issues and support human development. In the health sciences, UCI is noted for its research on cancer, the neurosciences and the genetic underpinnings of disease. UCI Medical Center, Orange County’s only university hospital and Level I trauma center, has been ranked among the nation’s best hospitals by U.S. News & World Report for 16 consecutive years.

UC Irvine parkA major intellectual and cultural center, UCI engages the community through public activities and events. Speakers on campus, for example, have included Nobel Peace Prize winners His Holiness the XIV Dalai Lama, former Soviet leader Mikhail Gorbachev and Iranian human rights activist Shirin Ebadi, all of whom also received the UCI Citizen Peacebuilding Award for their efforts toward world peace.

The university is also addressing the needs of the community and growing world population in an environmentally sustainable way. From the development of new and reliable processes for electricity and alternative fuels to critical water and waste management solutions, UCI consistently tops the list in Sierra magazine’s “Coolest Schools” report, its annual sustainability ranking of U.S. colleges and universities.  

A hub for innovation and entrepreneurship, the university collaborates with the community on many strategic partnerships such as UCI Applied Innovation , a center which brings campus-based discoveries together with Orange County’s vibrant business sector to support job creation and economic growth. Development also continues on the 185-acre University Research Park adjacent to campus, where R&D companies enjoy collaborative opportunities in medical research, biotechnology, engineering, computer science and business.

UCI is benefiting the community and the world in countless ways through its scholarly, scientific, creative and economic contributions. On its way to becoming a flagship UC campus and one of the nation’s very best universities, UCI has embarked on a strategic plan that will ensure the campus continues to inspire excellence as it fulfills its research, teaching and public service missions in the decades ahead.

Company info
Website
Telephone
949-824-5011
Location
University of California, Irvine
Irvine
CA
92697
US

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