Postdoctoral Research Associate_Calabrese Lab
Posting InformationPosition Information Position TitlePostdoctoral Research Associate_Calabrese LabVacancy IDPDS001253DepartmentPharmacology - 424001Position TypePostdoctoral Scholar Posting Details Salary RangeFull-time/Part-timeFull TimeIf part-time, hours per weekFTE1.0Proposed Start DateEstimated Duration of Appointment12 MonthsPosting Open Date03/02/2016Posting Close DateOpen Until FilledYesWork LocationChapel Hill, NCPosition Summary
The Calabrese laboratory is seeking a postdoctoral fellow to study molecular mechanisms of gene regulation induced by long noncoding RNAs (lncRNAs).
Project Details: Over 70% of the mammalian genome is transcribed and about half of the RNA species produced are classified as lncRNAs that have little or no potential to encode for protein. An emerging subset of lncRNAs play central roles in physiology and disease, yet their mechanisms of action remain poorly defined. Among this group are several lncRNAs, such as Xist, Kcnq1ot1,and Airn, that function to repress expression of genetically linked (i.e. adjacent) protein-coding genes. Misregulation of genes targeted for silencing by repressive lncRNAs can cause developmental lethality and a number of genetic disorders, including Rett, Klinefelter¹s, Triple X, Beckwith-Wiedemann, Silver-Russell, and Angleman¹s syndromes, which affect millions of individuals world-wide and are often untreatable beyond palliative measures. Broadly, we expect mechanistic insights gained from our work to provide the conceptual basis needed to develop strategies to correct pathological gene expression in the disorders listed above.
Ph.D. in related fieldQualifications and Experience
The successful candidate will have a Ph.D. in molecular biology, genetics, biochemistry, cell biology, computational biology, or a related field, a proven track record of research productivity, and enjoy participating interdisciplinary team science.Experience in quantitative microscopy, genomics, computational biology, and/or RNA biochemistry is also expected.Equal Opportunity Employer
The University of North Carolina at Chapel Hill is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender, gender expression, gender identity, genetic information, race, national origin, religion, sex, sexual orientation, or status as a protected veteran.Special Instructions
For information on UNC Postdoctoral Benefits and Services click hereQuick Linkhttp://unc.peopleadmin.com/postings/91412Special Physical and Mental Requirements
N/APosting Contact Information Department Contact Name and TitleJaneice Cox, HR ConsultantDepartment Contact Telephone or [email protected] Affairs Contact Information
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- Curriculum Vitae / Resume
- Cover Letter
- List of References
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