Postdoctoral Research Associate_Calabrese Lab
Posting InformationPosition Information Position Title Postdoctoral Research Associate_Calabrese Lab Vacancy ID PDS001253 Department Pharmacology - 424001 Position Type Postdoctoral Scholar Posting Details Salary Range Full-time/Part-time Full Time If part-time, hours per week FTE 1.0 Proposed Start Date Estimated Duration of Appointment 12 Months Posting Open Date 03/02/2016 Posting Close Date Open Until Filled Yes Work Location Chapel Hill, NC Position Summary
The Calabrese laboratory is seeking a postdoctoral fellow to study molecular mechanisms of gene regulation induced by long noncoding RNAs (lncRNAs).
Project Details: Over 70% of the mammalian genome is transcribed and about half of the RNA species produced are classified as lncRNAs that have little or no potential to encode for protein. An emerging subset of lncRNAs play central roles in physiology and disease, yet their mechanisms of action remain poorly defined. Among this group are several lncRNAs, such as Xist, Kcnq1ot1,and Airn, that function to repress expression of genetically linked (i.e. adjacent) protein-coding genes. Misregulation of genes targeted for silencing by repressive lncRNAs can cause developmental lethality and a number of genetic disorders, including Rett, Klinefelter¹s, Triple X, Beckwith-Wiedemann, Silver-Russell, and Angleman¹s syndromes, which affect millions of individuals world-wide and are often untreatable beyond palliative measures. Broadly, we expect mechanistic insights gained from our work to provide the conceptual basis needed to develop strategies to correct pathological gene expression in the disorders listed above.
Ph.D. in related fieldQualifications and Experience
The successful candidate will have a Ph.D. in molecular biology, genetics, biochemistry, cell biology, computational biology, or a related field, a proven track record of research productivity, and enjoy participating interdisciplinary team science.Experience in quantitative microscopy, genomics, computational biology, and/or RNA biochemistry is also expected.Equal Opportunity Employer
The University of North Carolina at Chapel Hill is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender, gender expression, gender identity, genetic information, race, national origin, religion, sex, sexual orientation, or status as a protected veteran.Special Instructions
For information on UNC Postdoctoral Benefits and Services click hereQuick Link http://unc.peopleadmin.com/postings/91412 Special Physical and Mental Requirements
N/APosting Contact Information Department Contact Name and Title Janeice Cox, HR Consultant Department Contact Telephone or Email [email protected] Postdoctoral Affairs Contact Information
If you experience any problems accessing the system or have questions about the application process, please contact the University’s Equal Employment Opportunity office at (919) 966-3576 or send an email to [email protected]
Please note: The Equal Employment Opportunity office will not be able to provide specific updates regarding position or application status.Applicant Documents Required Documents
- Curriculum Vitae / Resume
- Cover Letter
- List of References
Required fields are indicated with an asterisk (*).