Job description

Duties: The Gene Therapy Program (GTP) is entering a new era of unprecedented opportunity with great potential to reshape the face of medicine as we know it. Our discoveries have set the stage for successful treatments and possibly even cures for devastating genetic diseases.

The laboratory of Dr. Jim Wilson, at GTP of the University of Pennsylvania has been a leader in the development of innovative vector technology for close to three decades. We have emerged as the 'go-to' organization for public and private partners, who want to participate in the gene therapy space. Currently we are positioned to lead another round of vector innovation and establish pre-clinical and clinical proof-of-concept in therapeutic applications of in-vivo genome editing.

Due to significant growth, we are looking for a new, Research Specialist, Process Development (RSPD) to provide support to Senior Process Development Scientists to design, optimization and scale-up of mammalian cell culture processes suitable for cGMP manufacturing of AAV vectors.

As an RSPD, you will perform all upstream cell culture activities ranging from cell seeding, media development and optimization, cell line development, and bioreactor operation. You will investigate and compare scalable AAV production systems, perform laboratory experiments including DOE studies, process validation, process range, robustness, and troubleshooting studies. You will be involved in the development and use of in-process assays to monitor critical quality attributes. Also, you will be responsible for the ordering of supplies for PD activities.

You will work both independently and as part of a team to accomplish project goals within specified timelines and will participate in technology transfer processes both to internal production groups and contracted manufacturers.

Qualifications: BS in Biochemistry, Biology, or related disciplines and 1-3 years of relevant experience, or an equivalent combination of education and experience, are required.
Previous experience working with Process Development or Process Optimization strongly preferred
Must have strong technical experience with mammalian cell culture, including cell seeding, media optimization, or cell line development
Experience working with bioreactors strongly preferred
Must be highly motivated, have excellent organizational, communication and interpersonal skills.
Must be able to work independently and as part of a multi-disciplinary team.

Reference Number: 40-30733

Salary Grade: 025

Employment Type: Exempt

Org: DM-Gene Therapy Program

Special Requirements:

Job Family: I-Technical/Professional Research




Diversity Profile: University



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Job No:
Posted: 1/11/2019
Application Due: 1/11/2031
Work Type: Full Time