UNIV - Postdoctoral Scholar - Pharmacology

Location
Charleston, SC
Posted
Jan 07, 2019
Faculty Jobs
Arts & Humanities
Position Type
Postdoc
Institution Type
Four-Year Institution
UNIV - Postdoctoral Scholar - Pharmacology Job no: 510339
Entity: MUSC University
Department: COLLEGE OF MEDICINE - COM-Pharmacology
Sub Department: UNIV-2251020-Pharmacology Allocation & Reserves
Work type: Full-Time
Employee Type: UNIV - Post Doc
Location: Charleston, SC-Main Campus
Categories: Post Doctoral Scholar
Pay scale: UNIV-Band 0: Commensurate with experience.

Job Duties:30Will assist with daily maintenance of laboratory, training and supervision of technical staff, graduate students, and other laboratory personnel.Essential35Develop an independent research project in consultation with the PI. Individual will be responsible for the design and implementation of experiments in the area of signaling transduction and cancer biology. Must maintain accurate and up to date laboratory records. Will be responsible for presenting result to PI in individual and group meetings.Essential35Present work at local, regional, national and international meetings. Will be responsible for publication of results in leading scientific journals. Will work closely with PI to develop research grant proposals.Essential

Job summary: Seeking highly motivated individuals to work in the area of cellular signaling related to cancer development and progression. Candidates must have experience in molecular biology, biochemistry, and cell biology. Experience with animal models is preferred. Research in the laboratory is focused on two major areas: 1. RAS GTPase signaling and transformation; and 2. Compartmentalized signaling by the intersectin (ITSN) scaffold protein.

We have identified a novel allosteric regulatory site in RAS that is involved in the dimerization and nanoclustering of RAS at the plasma membrane (Spencer-Smith et. al. Nat. Chem. Biol, 2016 doi: 10.1038/nchembio.2231). Targeting this site blocks oncogenic RAS-mediated signaling and transformation by inhibiting RAS-induced dimerization and activation of the RAF kinase. Current studies are examining the role of RAS dimerization/nanoclustering in additional RAS effector pathways as well as using novel affinity reagents to probe isoform-specific differences in RAS signaling.

ITSN is a multi-domain scaffold protein involved in regulating endocytosis and cellular signaling (Herrero-Garcia and O’Bryan, Biochimica et Biophysica Acta, 1864, 2017, 23–30). However, overexpression of ITSN has been implicated in a number of human malignancies including neuroblastoma. Current projects center on ITSN’s role in regulating RAS family GTPases, lipid kinases, ubiquitin ligases, protein trafficking pathways, and the importance of these ITSN-regulated pathways in human disease, particularly cancer.

Individual will work closely with PI to develop an independent research project. It is expected that individual will work collaboratively with other members of the laboratory to further their project as well as other research projects in the laboratory. Good communication skills (both oral and written) are a must.

Payscale Salary Range: UNIV-Band 0: Commensurate with experience.

FLSA: Salaried

Minimum Experience and Training Requirements:

Physical Requirements: Ability to perform job functions in an upright position. (Frequent) Ability to perform job functions in a seated position. (Continuous) Ability to perform job functions while walking/mobile. (Frequent) Ability to climb, using step stool. (Infrequent) Ability to work in temperature extremes (32? F to 100? F) when required due to assignments in cold rooms and/or foreign countries. (Infrequent) Ability to work in confined/cramped spaces. (Continuous) Ability to bend at the waist. (Frequent) Ability to twist at the waist. (Frequent) Ability to fully use both hands/arms. (Continuous) Ability to perform repetitive motions with hands/wrists/elbows and shoulders. (Frequent) Ability to fully use both legs. (Frequent) Ability to reach in all directions, stretch, bend, while moving items/materials from both sitting and standing positions. (Frequent) Ability to maintain good olfactory sensory function/distinction. (Continuous) Ability to lift materials up to 20 lbs., unassisted. (Infrequent) Ability to lift and carry 4 liter waste material bottles a distance of 30 feet, unassisted. (Frequent) Ability to lift and carry 25-30 lbs. jugs of liquid a distance of 100 feet, unassisted. (Infrequent) Ability to lift file boxes, from floor level to counter tops, unassisted. (Frequent) Ability to push/ Ability to lift 40 lbs. centrifuge rotors from floor level to height of 40 inches, then down 20 inches into centrifuge drum, unassisted. (Infrequent) Ability to lift 25 lbs. boxes, from floor level to maximum height of 72 inches, unassisted. (Infrequent) Ability to push/pull file boxes from one location to another at floor level. (Frequent) Ability to maneuver heavy equipment on bench tops, 50 lbs. or greater, unassisted. (Frequent) Ability to perform gross motor functions with frequent fine motor movements. (Continuous) Ability to maintain 20/20 vision, corrected. (Continuous) Ability to match or discriminate between colors, normally. (Continuous) Ability to hear and recognize various alarms emitting from work area systems. (Continuous) Ability to hear and/or understand conversations. (Continuous) Ability to work in a darkroom for processing film, etc. (Continuous) Ability to be qualified physically for respirator use, initially and annually. (Continuous)


Opening date: 24 Oct 2018 Eastern Daylight Time
Applications close:

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