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Postdoctoral Fellow in Parasitic Diseases: Drug Discovery and Therapeutics

Employer
Loyola University Chicago
Location
Maywood-Health Sciences Campus

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Faculty Jobs
Science & Technology, Chemistry & Biochemistry, Life Sciences
Position Type
Postdoc
Employment Type
Full Time
Institution Type
Four-Year Institution
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Job Details

Job Title:

Postdoctoral Fellow in Parasitic Diseases: Drug Discovery and Therapeutics

Position Title:

Postdoctoral Fellow in Parasitic Diseases: Drug Discovery and Therapeutics

Job Category:

University Faculty

Job Type:

Full-Time

FLSA Status:

Exempt

Campus:

Maywood-Health Sciences Campus

Location Code:

DEPARTMENT OF MEDICINE (06500A)

Duties and Responsibilities:

Searching for a post-doctoral research fellow in the Department of Medicine, Loyola University Medical Center, Chicago, USA. Our primary focus is to develop high throughput screening methods for identifying lead compounds using new drug libraries, synthetic molecules, approved drugs and natural products for treating protozoan diseases, specifically Malaria, Leishmaniasis, Chagas disease and Toxoplasmosis. These parasites are still continuing to be threat globally, currently no vaccines and treatment primarily depended on pharmacotherapy. Rapid emergence of drug resistance to commonly used drugs, coupled with limited availability of second-line therapeutics creates an immediate need to discover new and effective drugs. Besides the problem of drug resistance and toxicity, currently used drugs cause adverse effects on the host immune system (immune dysregulation). Therefore, our approach is to discover and develop drugs that target parasite as well have beneficial effect on the host immune response. Furthermore, we will utilize in-silico analysis, including molecular docking and structure-based screening to identify putative targets, mechanisms of actions of each lead compounds and in-vitro enzymatic assays to validate. Our lab is also interested in understanding the molecular and biological mechanisms underlying anemia caused by inflammation using an in-vitro erythropoiesis model.

Qualifications:

We seek highly motivated researcher with previous experience of working with at least one of the parasite, drug discovery and/or therapeutic development areas. Required skills include tissue culture, parasite culture, in-vitro screening in parasites, flow cytometry, RT-PCR, microscopy imaging, functional enzymatic assays and related molecular biology techniques. Applicants should have excellent writing skills and able to work both independently and collaboratively. Applicants should have a Ph.D. (or expected to receive a Ph.D.) in the biomedical sciences or M.D. equivalent at the time of joining the lab.

Minimum Education and/or Work Experience:

Searching for a post-doctoral research fellow in the Department of Medicine, Loyola University Medical Center, Chicago, USA. Our primary focus is to develop high throughput screening methods for identifying lead compounds using new drug libraries, synthetic molecules, approved drugs and natural products for treating protozoan diseases, specifically Malaria, Leishmaniasis, Chagas disease and Toxoplasmosis. These parasites are still continuing to be threat globally, currently no vaccines and treatment primarily depended on pharmacotherapy. Rapid emergence of drug resistance to commonly used drugs, coupled with limited availability of second-line therapeutics creates an immediate need to discover new and effective drugs. Besides the problem of drug resistance and toxicity, currently used drugs cause adverse effects on the host immune system (immune dysregulation). Therefore, our approach is to discover and develop drugs that target parasite as well have beneficial effect on the host immune response. Furthermore, we will utilize in-silico analysis, including molecular docking and structure-based screening to identify putative targets, mechanisms of actions of each lead compounds and in-vitro enzymatic assays to validate. Our lab is also interested in understanding the molecular and biological mechanisms underlying anemia caused by inflammation using an in-vitro erythropoiesis model.

We seek highly motivated researcher with previous experience of working with at least one of the parasite, drug discovery and/or therapeutic development areas. Required skills include tissue culture, parasite culture, in-vitro screening in parasites, flow cytometry, RT-PCR, microscopy imaging, functional enzymatic assays and related molecular biology techniques. Applicants should have excellent writing skills and able to work both independently and collaboratively. Applicants should have a Ph.D. (or expected to receive a Ph.D.) in the biomedical sciences or M.D. equivalent at the time of joining the lab.

Interested applicants should submit a cover letter, CV and contact information of three references to: [email protected]

Open Date:

12/14/2018

Special Instructions to Applicants:

Interested applicants should submit a cover letter, CV and contact information of three references to: [email protected]

Quick Link for Posting:

https://www.careers.luc.edu/postings/9915

Organizational Location:

HEALTH SCIENCES CAMPUS

Number of Vacancies:

1

Open Until Filled:

Yes

Organization

Working at Loyola University Chicago

Loyola University Chicago, a private university founded in 1870 as St. Ignatius College, is the nation’s largest Jesuit, Catholic University and the only one located in Chicago. Shaped by our city and our Jesuit traditions, Loyola University Chicago offers students an educational environment unmatched for its diversity of thought and experience.

Loyola University Chicago comprises four campuses: Lake Shore (LSC), Water Tower (WTC), Health Sciences (HSC), and the John Felice Rome Center in Italy, and is home to eleven schools and colleges: Arrupe College, Quinlan School of Business, Marcella Niehoff School of Nursing, Stritch School of Medicine, College of Arts and Sciences, School of Communication, School of Continuing and Professional Studies, School of Education, School of Law, School of Social Work, and Graduate School. Loyola also features course locations in Beijing, China; Saigon-Ho Chi Minh City, Vietnam; Vernon Hills, Illinois (Cuneo Mansion and Gardens); and a Retreat and Ecology Campus in Woodstock, Illinois.

With three campuses spread throughout the greater Chicago area, students have access to hundreds of cultural institutions as well as thousands of internships and networking opportunities with the city's Fortune 500 companies. Study-abroad programs at our Rome and Beijing Centers provide engagement with the global community and economy.

While rigorous programs of research and study are one hallmark of a Jesuit education, we're not just preparing students for a career, we're preparing them for life. We challenge our students to learn broadly, to think critically, to serve generously, to lead with integrity, to respect diversity. We come from all faiths and ethnic and economic backgrounds, with a common purpose of building a better society.

Recognizing Loyola’s excellence in education, U.S.News and World Report has ranked Loyola consistently among the "top national universities" in its annual publications, and named the University a "best value" in its 2008 rankings.

Our faculty take a person-centered approach to education. They’re not just here to teach students what they know, they’re here to teach them to think critically and creatively and to reach for their own discoveries.

More facts about Loyola University Chicago:

  • Total enrollment: 15,902
  • 80+ undergraduate majors and 80+ minors
  • 140+ graduate, professional, and graduate-level certificate programs
  • More than 4,000 faculty and staff members 
  • 14:1 Undergraduate student/faculty ratio 
  • 150,000 alumni; 85,000 in Chicago 
  • One of only eight percent of all American colleges and universities to have a Phi Beta Kappa honor society chapter
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