Postdoctoral Fellow in Parasitic Diseases: Drug Discovery and Therapeutics

Job description

Position Details

Position Details

Job TitlePostdoctoral Fellow in Parasitic Diseases: Drug Discovery and TherapeuticsPosition TitlePostdoctoral Fellow in Parasitic Diseases: Drug Discovery and TherapeuticsPosition NumberJob CategoryUniversity FacultyJob TypeFull-TimeFLSA StatusExemptCampusMaywood-Health Sciences CampusLocation CodeDEPARTMENT OF MEDICINE (06500A)Department NameIs this split and/or fully grant funded? Duties and Responsibilities

Searching for a post-doctoral research fellow in the Department of Medicine, Loyola University Medical Center, Chicago, USA. Our primary focus is to develop high throughput screening methods for identifying lead compounds using new drug libraries, synthetic molecules, approved drugs and natural products for treating protozoan diseases, specifically Malaria, Leishmaniasis, Chagas disease and Toxoplasmosis. These parasites are still continuing to be threat globally, currently no vaccines and treatment primarily depended on pharmacotherapy. Rapid emergence of drug resistance to commonly used drugs, coupled with limited availability of second-line therapeutics creates an immediate need to discover new and effective drugs. Besides the problem of drug resistance and toxicity, currently used drugs cause adverse effects on the host immune system (immune dysregulation). Therefore, our approach is to discover and develop drugs that target parasite as well have beneficial effect on the host immune response. Furthermore, we will utilize in-silico analysis, including molecular docking and structure-based screening to identify putative targets, mechanisms of actions of each lead compounds and in-vitro enzymatic assays to validate. Our lab is also interested in understanding the molecular and biological mechanisms underlying anemia caused by inflammation using an in-vitro erythropoiesis model.

Qualifications

We seek highly motivated researcher with previous experience of working with at least one of the parasite, drug discovery and/or therapeutic development areas. Required skills include tissue culture, parasite culture, in-vitro screening in parasites, flow cytometry, RT-PCR, microscopy imaging, functional enzymatic assays and related molecular biology techniques. Applicants should have excellent writing skills and able to work both independently and collaboratively. Applicants should have a Ph.D. (or expected to receive a Ph.D.) in the biomedical sciences or M.D. equivalent at the time of joining the lab.

Physical DemandsWorking ConditionsMinimum Education and/or Work Experience

Searching for a post-doctoral research fellow in the Department of Medicine, Loyola University Medical Center, Chicago, USA. Our primary focus is to develop high throughput screening methods for identifying lead compounds using new drug libraries, synthetic molecules, approved drugs and natural products for treating protozoan diseases, specifically Malaria, Leishmaniasis, Chagas disease and Toxoplasmosis. These parasites are still continuing to be threat globally, currently no vaccines and treatment primarily depended on pharmacotherapy. Rapid emergence of drug resistance to commonly used drugs, coupled with limited availability of second-line therapeutics creates an immediate need to discover new and effective drugs. Besides the problem of drug resistance and toxicity, currently used drugs cause adverse effects on the host immune system (immune dysregulation). Therefore, our approach is to discover and develop drugs that target parasite as well have beneficial effect on the host immune response. Furthermore, we will utilize in-silico analysis, including molecular docking and structure-based screening to identify putative targets, mechanisms of actions of each lead compounds and in-vitro enzymatic assays to validate. Our lab is also interested in understanding the molecular and biological mechanisms underlying anemia caused by inflammation using an in-vitro erythropoiesis model.

We seek highly motivated researcher with previous experience of working with at least one of the parasite, drug discovery and/or therapeutic development areas. Required skills include tissue culture, parasite culture, in-vitro screening in parasites, flow cytometry, RT-PCR, microscopy imaging, functional enzymatic assays and related molecular biology techniques. Applicants should have excellent writing skills and able to work both independently and collaboratively. Applicants should have a Ph.D. (or expected to receive a Ph.D.) in the biomedical sciences or M.D. equivalent at the time of joining the lab.

Interested applicants should submit a cover letter, CV and contact information of three references to: [email protected]

Open Date12/14/2018Close DateSpecial Instructions to Applicants

Interested applicants should submit a cover letter, CV and contact information of three references to: [email protected]

Quick Link for Postinghttp://www.careers.luc.edu/postings/9915Job NumberOrganizational LocationProvost Health Sciences DivisionPosting Details

Posting Detail

Number of Vacancies1Desired Start DatePosition End DateOpen Until FilledYesApplicant DocumentsRequired Documents
  1. Curriculum Vitae
Optional Documents
  1. Cover Letter/Letter of Application
  2. Teaching Statement
  3. Research Statement
  4. Writing Sample
  5. Scholarly Publications
  6. Teaching Evaluations
  7. Other Document
  8. Unofficial Transcripts
  9. Multi Media
  10. Resume
Supplemental Questions

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    Job No:
    Posted: 12/29/2018
    Application Due: 11/26/2019
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