Post-Doctoral Fellow - Mitra Lab (HemOncBMT)

Job description

University of Colorado Denver l Anschutz Medical Campus

Department of Pediatrics

Section of Hematology, Oncology and Bone Marrow Transplantation

Post-Doctoral Fellow - Mitra Lab

Position #754976 - Requisition #14847

The University of Colorado Denver l Anschutz Medical Campus seeks individuals with demonstrated commitment to creating an inclusive learning and working environment. We value the ability to engage effectively with students, faculty and staff of diverse backgrounds.

The University of Colorado Denver | Anschutz Medical Campus is a public research university serving more than 18,000 students. We award nearly 4,000 degrees each year, including more graduate and professional degrees than any other Colorado institution. With our solid academic reputation, award-winning faculty and renowned researchers, we offer more than 140 highly rated degree programs through 13 schools and colleges. The university receives over $400 million in research awards each year. In addition to the wide array of health-related programs and facilities offered at CU Anschutz in Aurora, Colo. a significant number of undergraduate and graduate degree programs are taught at CU Denver, our comprehensive campus in the heart of downtown Denver-one of America's most vibrant urban centers. CU Denver is located steps from the Denver Center for Performing Arts and the LoDo District affording our students, faculty and staff access to a broad array of academic, professional, community, recreational and cultural outlets.

The University of Colorado Anschutz Medical Campus ranks among the top institutions nationally in clinical care, education and research. Its 230-acre campus, designed to enhance collaboration and interprofessional education, hosts the College of Nursing; the Schools of Dental Medicine, Medicine, Pharmacy, and Public Health; the Graduate School; a Health Sciences Library; and two hospitals. Strategically located contiguous to the campus are a biosciences research park and the Veterans Hospital. CU Anschutz offers two undergraduate degrees, 35 graduate degrees, and five first-professional programs. More than 4,000 students learn alongside faculty members who also make meaningful medical discoveries and provide expert clinical care through 1.5 million patient-visits annually. A hub for research and innovation, CU Anschutz receives over $400 million in research awards each year and has filed 1,300 patent applications and formed 53 new companies since 2002.

A national leader in health care and life sciences, CU Anschutz is the only comprehensive academic health sciences center in Colorado and the largest in the Rocky Mountain region. Located in Aurora, Colo., it is one of the newest education, research and patient care facilities in the world. With six schools and colleges, CU Anschutz trains the health sciences workforce of the future by blending education, research and clinical care all in one place. This strategic collaboration among diverse health care fields allows knowledge to travel directly from the research bench to the patient's bedside. Read CU Anschutz Quick Facts here.

Job Summary/Scope of Research:

The Mitra lab is part of the Morgan Adams Pediatric Brain Tumor Research Program within the Department of Pediatrics, Section of Hematology, Oncology, Bone Marrow Transplantation at the University of Colorado, School of Medicine based in Denver, Colorado. The Mitra lab brings together three distinct fields of research: Immuno-Oncology, neurodevelopment, and brain tumor oncology. The lab focuses on the mechanisms of immune-surveillance in brain tumors by cells of the innate immune system. As one of the earliest immunologic defense mechanisms developed in the body, is independent of mutational load and provides a unique effector mechanisms of macrophages and brain resident microglia that are often present in high numbers within the brain tumor microenvironment. While most studies have demonstrated tumor-associated macrophages to promote tumor growth, we have recently shown that inhibiting the myeloid checkpoint pathway (the CD47-SIRP signaling axis) suppresses the "don't eat me" signal and allows for efficient macrophage-mediated phagocytosis of different types of brain tumors (Science Translation Medicine, 15 Mar 2017) and are now continuing our investigations on understanding the immune microenvironment and immune-evasion pathways in brain tumors. A major interest of the laboratory focuses on translational immune-Oncology to understand and leverage the mechanisms of efferocytosis and immunogenic cell death to develop better immune modulating drugs against adult and pediatric brain tumors. The members of the lab will be part of a unique brain tumor research program which encompasses seven labs whose expertise ranges from single cell RNA sequencing, autophagy and oncogenic signaling pathway.

  • Analysis of patient brain tumor samples.
  • Perform and analyze genomic/transcriptomic techniques.
  • Collaborate with other investigators inside and outside of the CU system
  • Perform experiments independently as well as experiments with other students, postdocs to contribute to publications and overall productivity of the group.
  • Maintain accurate and current laboratory notebook including all experimental details.
  • Write-up and present experiments in small group meetings.

PLEASE NOTE: Candidates will be responsible for travel expenses related to the interview process and any relocation expenses, if applicable.

Salary and Benefits:

The hiring salary for this position is $49,188 and is negotiable and commensurate with skills and experience. This position is not eligible for overtime compensation.

The University of Colorado offers a full benefits package. Information on University benefits programs, including eligibility, is located at Employee Services.

The University of Colorado Denver | Anschutz Medical Campus is dedicated to ensuring a safe and secure environment for our faculty, staff, students and visitors. To assist in achieving that goal, we conduct background investigations for all prospective employees.

The Immigration Reform and Control Act requires that verification of employment eligibility be documented for all new employees by the end of the third day of work. Alternative formats of this ad are available upon request for persons with disabilities.

Your total compensation goes beyond the number on your paycheck. The University of Colorado provides generous leave, health plans and retirement contributions that add to your bottom line.


Total Compensation Calculator: (for questions please contact [email protected])

Diversity and Equity:

Please click here for information on disability accommodations:

The University of Colorado Denver | Anschutz Medical Campus is committed to recruiting and supporting a diverse student body, faculty and administrative staff. The university strives to promote a culture of inclusiveness, respect, communication and understanding. We encourage applications from women, ethnic minorities, persons with disabilities and all veterans. The University of Colorado is committed to diversity and equality in education and employment.


Minimum Qualifications:

  • Graduation from an accredited university with a PhD, MD or DO degree.
  • Demonstrates the proficiency in computer software, equipment operation, or research technical skills.

Condition of Employment:

  • Must be willing and able to pass a national criminal background check

Preferred Qualifications:

In depth experience in at least two of the following areas is desired:

  • Experience with multi-coloring flow cytometry;
  • in vivo cellular immunology in the mouse model;
  • experience with mouse engineering for cancer research.

Knowledge, Skills and Abilities:

  • Ability to communicate effectively.
  • Ability to work on a team and independently.
  • Knowledge of techniques to analyze brain tumor samples.
  • Ability to present experiments in small group settings.

Special Instructions to Applicants:Special Instructions to Applicants *Applications are accepted electronically ONLY at Required Application Materials: When applying at, applicants must include: 1. A cover letter of application which specifically addresses the job requirements and outlines qualifications 2. A current CV or resume 3. The names, addresses, daytime telephone numbers and email addresses for three professional references. Questions should be directed to Sid Mitra at [email protected]

Reference checks are a standard step in our hiring process. You may be asked to provide contact information, including e-mail addresses, for up to 5 references if you are referred to the Hiring Authority for an interview. We will notify you prior to contacting both on and off-list references. Please do not submit any of your application material (via email) to the job posting contact.

Application Materials Required:Cover Letter, Resume/CV, List of References

Application Materials Instructions:APPLICATION DEADLINE: - Applications will be accepted until the position is filled.

Job Category: Faculty

Primary Location: Aurora

Department: H0001 -- Anschutz Medical Campus - 20877 - SOM-PEDS Hematology-Onc-GenOps

Schedule: Full-time

Posting Date: Oct 2, 2018

Closing Date: Ongoing

Posting Contact Name: Siddhartha Mitra

Posting Contact Email: [email protected]

Position Number: 00754976





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Job No:
Posted: 12/2/2018
Application Due: 1/31/2019
Work Type: