PRA Bioinformatics-Doebele lab

Job description

University of Colorado - School of Medicine

Lung Cancer Program Professional Research Assistant (PRA)

Doebele Research Lab
Working Title: Bioinformatics Data Analyst I

Job Summary: Now hiring for a full-time PRA with benefits. The candidate will work as a Bioinformatics Analyst I in collaboration with Medical Oncology and the Department of Anesthesiology with Eric Clambey, PhD, Assistant Professor. The position is located within a research laboratory located at the University of Colorado Anschutz Medical Campus in Aurora, Colorado. This position reports directly to Robert C. Doebele, MD, PhD, PI and is supervised both by the faculty investigator and Dr. Clambey, who will also provide mentorship. This is a research technician position in the Doebele laboratory.

Primary duties may include the following: Performing bioinformatic analysis of high-content datasets (mass cytometric analysis and multiplexed immunohistochemistry) in the study of lung cancer. The candidate will be expected to work collaboratively with Dr. Clambey and other lung cancer researchers at the University of Colorado involved in the Thoracic Oncology Research Initiative (TORI) and/or the University of Colorado Lung Cancer SPORE to facilitate bioinformatic analysis of mass cytometric analysis and multiplexed immunohistochemistry.

Professional Field: The research will focus on lung cancer, from animal models to patient samples, ranging from pre-malignancy to stage IV lung cancer. The primary goal of this research is to define the tumor microenvironment across multiple states, to elucidate the cellular and molecular factors that regulate lung cancer progression.

Examples of work performed (ordered in frequency of tasks):

  • Data processing and analysis of high-content data from human and mouse lung cancer-related research projects, with a primary focus on CyTOF and Vectra datasets.
  • Meeting with Dr. Clambey and lung cancer collaborators to discuss experimental design, analysis and interpretation of high-content datasets.
  • Establishing workflow for standardized data analysis of CyTOF and Vectra data.
  • Implementing and troubleshooting use of new, published algorithms to facilitate improved analysis.
  • Keeping detailed records on analysis across multiple research projects.
  • Attending and contributing to research meeting discussion.
  • Assistance with manuscript preparation, including methods description and figure generation.
  • The primary focus of this position is to make use of established algorithms for data analysis, with little to no development of new algorithms.
  • Supervision exercised: After initial training in bioinformatic analysis specific to the defined research projects, the Bioinformatic Analyst may be involved in the training and supervision of junior members of the laboratory, or other lung cancer investigators, in performing data analysis.
  • Participation in weekly research laboratory group meetings and applicable trainings as required;
  • Flexible in learning new technical skills related to research;
  • Other research laboratory duties as assigned by the faculty investigator.

Knowledge, Skills, and Abilities

  • Foundational knowledge of biological systems and the immune system.
  • Excellent computer skills, including proficiency with R, Adobe Illustrator, GraphPad Prizm, and Microsoft Office.
  • Ability to work under guidance of faculty member proficient in CyTOF analysis, with analysis done in consultation with requesting laboratory.
  • Background in cancer research and flow cytometry beneficial, but not required.

Working Conditions / Hours: The position requires 100% effort working within the secured research laboratory and applicable facilities. Note; working in the evening or working on weekends may be required and reviewed on a project-by-project basis within the research laboratory. The position is exempt from overtime pay.

Salary and Benefits:

Salary is commensurate with skills and experience. The University of Colorado offers a full benefits package. Information on University benefits programs, including eligibility, is located at Employee Services.

The University of Colorado Denver is dedicated to ensuring a safe and secure environment for our faculty, staff, students and visitors. To assist in achieving that goal, we conduct background investigations for all prospective employees.

The Immigration Reform and Control Act requires that verification of employment eligibility be documented for all new employees by the end of the third day of work. Alternative formats of this ad are available upon request for persons with disabilities.

Your total compensation goes beyond the number on your paycheck. The University of Colorado provides generous leave, health plans and retirement contributions that add to your bottom line.


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Diversity and Equity:

Please click here for information on disability accommodations:

The University of Colorado Denver | Anschutz Medical Campus is committed to recruiting and supporting a diverse student body, faculty and administrative staff. The university strives to promote a culture of inclusiveness, respect, communication and understanding. We encourage applications from women, ethnic minorities, persons with disabilities and all veterans. The University of Colorado is committed to diversity and equality in education and employment.


Minimum Qualifications:

  • Graduation from an accredited college or university a BS/BA in relevant biological sciences field is required.
  • Minimum 2 years previous bench research experience.
  • Prior experience in analysis of mass cytometry data.
  • Prior experience in analysis of immunohistochemistry data.
  • Strong ability to quickly adapt to new challenges, willingness to learn, attention to detail and ability to communicate with users and generate figures.
  • Excellent communication and interaction skills, organizational and computer competency skills (MS Office), internet for official University of Colorado business use.

Desired Qualifications:

The ideal candidate will have significant experience:

  • Highly valued prior research experience working with bioinformatics, data mining, is preferred.
  • Strong computer programming skills is a plus.
  • Prefer finalist that is team-oriented, flexible, ability to work both independently and within a team environment as well as work effectively with time-sensitive data to meet deadlines.
  • Prior experience preferred with ability to handle and process detail-oriented documentation and meet designated research deadlines. Demonstrated experience with research databases is desired.
  • Must be a U.S. Citizen, U.S. Permanent resident, or a foreign national holding a valid and appropriate visa.

In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and to complete the required employment eligibility verification form upon hire.

    Application Materials Required:Cover Letter, Resume/CV, List of References, Unofficial transcript(s)

    Application Materials Instructions:Applications are accepted electronically at CU Careers, refer to requisition ID: 15226 When applying, applicants must include: 1. A letter of application which specifically addresses the job requirements and outlines qualifications. 2. A current Resume/CV 3. The names, addresses, daytime telephone numbers and e-mail addresses for three professional work references, either attached to your resume/CV or uploaded as a separate document Please be advised that the University does check references as part of the employment process. Please do not submit any of your application material (via email) to the job posting contact.

    Job Category: Faculty

    Primary Location: Aurora

    Department: H0001 -- Anschutz Medical Campus - 20214 - SOM-MED-Oncology

    Schedule: Full-time

    Posting Date: Nov 29, 2018

    Closing Date: Ongoing

    Posting Contact Name: Everlyn Sandoval

    Posting Contact Email: [email protected]

    Position Number: 00756423





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    Job No:
    Posted: 11/30/2018
    Application Due: 12/15/2018
    Work Type: