Job description

Duties: The Gene Therapy Program (GTP) is entering a new era of unprecedented opportunity with the great potential to reshape the face of medicine, as we know it. Our discoveries have set the stage for successful treatments and possibly even cures for devastating genetic diseases. GTP is a complex R&D organization consisting of research laboratories supported by multiple core functions which provide internal capacity to perform gene transfer studies from basic research through Phase 1 proof-of-concept human trials.

The laboratory of Dr. Jim Wilson, at GTP of the University of Pennsylvania, has been a leader in the development of innovative vector technology for close to three decades. We have emerged as the 'go-to' organization for public and private partners, who want to participate in the gene therapy space. Currently, we are positioned to lead another round of vector innovation and establish pre-clinical and clinical proof-of-concept in therapeutic applications of in-vivo genome editing.

Our Program of Comparative Medicine is expanding, and as part of that expansion, we are looking to add a Lead, Transgenic Colony Management to oversee, monitor, and support colony management activities for all rodent breeding colonies maintained by GTP.

As a Lead, Transgenic Colony Management, you will manage all routine and complex breeding of rodent colonies. You will partner with Study Directors to establish cohort needs, measuring progress and addressing all issues that arise. You will maintain adequate number of animals by set up breeding pairs, manage breeding rotations and setting up timed pregnancies. You will wean and identify pups and genotype each animal in order to generate homozygous or transgenic lines and maintain appropriate breeding schemes per strain. You will observe rodents for obvious phenotype and perform a natural history analysis when necessary. You will maintain detailed and accurate records (GLP and non-GLP) for all colonies and perform record audits as needed to ensure accuracy and maintain compliance. Also, you will perform other technical research procedures (dosing, injections, sample collections, etc.) and husbandry activities as needed.

Employees in this position will participate in an occupational safety and health program which may require tuberculin testing and potentially immunization. Weekend work, holiday work and overtime hours are a requirement of this position. May be designated as essential personnel during a storm/natural disaster. Responsibilities must be performed with minimal instruction and persons will be expected to independently perform duties as described.

Qualifications: Master's Degree in a life science with 3 to 5 years of relevant experience working with transgenic animal models or equivalent combination of education and experience required.
LAT ALALAS certification strongly preferred
Must have experience handling rodents and other lab animals
Must have experience with rodent breeding programs and have a working knowledge of breeding, weaning, and record-keeping
GLP experience preferred but not required
Excellent demonstrated accuracy, attention to detail and work ethic a must!
Excellent oral and written communication skills, including demonstrated ability to communicate effectively with all levels of staff
Must have a demonstrated ability to foster positive relationships with co-workers and researchers
Must have a demonstrated ability to work independently, with minimal supervision.

Reference Number: 40-30260

Salary Grade: 027

Employment Type: Exempt

Org: DM-Gene Therapy Program

Special Requirements:

Job Family: I-Technical/Professional Research




Diversity Profile: University



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Job No:
Posted: 11/1/2018
Application Due: 1/10/2019
Work Type: