Research Associate - Structural Biologist

Job description

Research Associate - Structural Biologist Hiring department Mbs-PI-Lambowitz Monthly salary $4,167+ depending on qualifications Hours per week 40.00 Flexible from 700AM to 700PM Posting number 18-02-12-01-0708 Job Status Open FLSA status Exempt Earliest Start Date Immediately Position Duration Terminates on unknown date Position open to all applicants Location Austin (main campus) Number of vacancies 1 General Notes All applicants must submit a letter of interest, current CV including analysis of publications listed, and three letters of reference/recommendation - two of the three must be from outside UT-Austin. This position is for one year with the possibility of renewal based on performance and available research funding.

Required Application Materials
  • A Resume is required in order to apply
  • A Letter of Interest is required in order to apply.
Note: The following additional materials are also required for consideration: 3 letters of recommendation - 2 of the 3 letters must be from outside UT Instructions for submission of these materials will be provided at the time the online application has been completed.

Additional Information Purpose To research, with a high degree of independence, the structure, function and mechanism of group II intron reverse transcriptases and related enzymes.

Essential Functions Express, purify, and characterize full-length and deletion constructs of group II intron reverse transcriptases and related proteins for structural analysis and biotechnological applications, using Fast Protein Liquid Chromatography FPLC and other methods. Characterize wild-type and mutant proteins biochemically and determine conditions under which proteins crystallize in the absence or presence of substrates by sitting or hanging drop methods. Carry out biochemical and biophysical assays. Use in vitro mutagenesis to construct and characterize mutant group II intron reverse transcriptases to modify their biochemical activities. Obtain X-ray crystal structures of reverse transcriptases and related enzymes and their nucleic acid-protein complexes. Test if crystals are suitable for structure determination by X-ray diffraction. Solve structures by crystallographic methods. Obtain SAXS and Cryo-EM structures and other biophysical data for proteins and nucleic acid-protein complexes and construct models for their solution structures. Write manuscripts and assist in the preparation of reports, abstracts, manuscripts and proposals. Make presentations at lab meetings; attend lab meetings and other meetings. Order chemicals and supplies specific to current project. Provide instruction, assistance and mentoring to graduate students.

Marginal/Incidental functions Other related functions as assigned.

Required qualifications PhD in biochemistry, biophysics, molecular biology, structural biology or closely related field. History of research productivity as evidenced by a strong publication record. Demonstrated ability to exercise a high degree of independent judgment. Strong written and verbal communication skills and excellent attention to detail. Demonstrated ability to work well with a culturally diverse group of faculty, staff, and students, including the willingness and ability to mentor graduate students. Equivalent combination of relevant education and experience may be substituted as appropriate.

Preferred Qualifications Demonstrated ability to crystallize proteins and solve structures. Experience with biochemical and biophysical assays. Three years of post-doctoral experience in a relevant field.

Working conditions Uniforms and/or personal protection equipment (furnished) May work around chemical fumes May work around standard office conditions May work around biohazards May work around chemicals Repetitive use of a keyboard at a workstation Use of manual dexterity

A criminal history background check will be required for finalist(s) under consideration for this position.

The retirement plan for this position is Teacher Retirement System of Texas (TRS), subject to the position being at least 20 hours per week and at least 135 days in length. This position has the option to elect the Optional Retirement Program (ORP) instead of TRS, subject to the position being 40 hours per week and at least 135 days in length.

The University of Texas at Austin, as an equal opportunity/affirmative action employer, complies with all applicable federal and state laws regarding nondiscrimination and affirmative action. The University is committed to a policy of equal opportunity for all persons and does not discriminate on the basis of race, color, national origin, age, marital status, sex, sexual orientation, gender identity, gender expression, disability, religion, or veteran status in employment, educational programs and activities, and admissions.

If hired, you will be required to complete the federal Employment Eligibility Verification form, I-9. You will be required to present acceptable, original documents to prove your identity and authorization to work in the United States. Information from the documents will be submitted to the federal E-Verify system for verification. Documents must be presented no later than the third day of employment. Failure to do so will result in dismissal.

UT Austin is a Tobacco-free Campus

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Job No:
Posted: 10/4/2018
Application Due: 10/4/2027
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