Research Assistant Professor (Whitmire)
Position Type: Permanent Faculty
Department: Genetics - 423501
Appointment Type: Fixed Term Faculty
Vacancy ID: FAC0002519
Position Summary: The Whitmire lab studies immune defenses against virus infections, focusing on how T cells develop and contribute to infection control or pathogenesis. The Whitmire lab seeks a Research Assistant Professor who will lead several interdisciplinary projects. The three distinct projects will involve advanced molecular immunology, cellular immunology, and genetics, using modern methods to quantify T cell responses, gene expression, and infection levels in virus-infected mice. The researcher will (1) map loci contributing to viral hemorrhagic disease, (2) examine the impact of obesity on host defense, and (3) examine T cell-liver interactions during virus infection. The immunologist will be technically, managerial, and intellectually engaged in these projects, and will play a central role in associated collaborations. This research is interdisciplinary and requires advanced expertise in cellular immunology and virology. The investigator will also serve a managerial role in the lab and assist in guiding trainees (graduate students, technicians, new post-docs) in the lab.
Application Deadline: 09/26/2018
Education Requirements: PhD, MD/PhD in biological sciences.
Qualification and Experience: Essential: *Advanced knowledge of cellular immunology, molecular immunology, and virus-host interactions. *Experience working with virus at BSL2 and ABSL2 conditions; growth of virus in cell culture; virus plaque assays; quantification of virus RNA. *Experience working with mice, including mouse handling, breeding, Cre/flox approaches, genotyping, PCR design, forward genetics; infections of mice and related ABSL2 work; adoptive transfers of leukocytes, bone marrow chimeras. *Experience working with T cells, including leukocyte isolation from lymphoid tissues, non-lymphoid tissues, liver, and adipose; T cell culture, T cell differentiation; flow cytometry-based analyses of T cell frequency and activity; T cell proliferation and T cell apoptosis assays; ELISA-based measures of cytokines and virus-specific antibody. *Experience in FloJo, Prism, Excell, statistics. *Experience in gene/protein expression analyses. *Excellent organization and communication skills for sustaining collaborations, writing papers, oral presentations. Preferred: *Post-doctoral research experience in viral immunology; *Experience working with RNA viruses and/or hemorrhagic viral diseases; *Experience with mouse genetics, forward genetics, and genomic analyses; *Experience in histology of lymphoid tissue, lung, liver, adipose; confocal microscope. *Experience in bioinformatic analyses of genonic sequence variants and gene expression, bioinformatic analyses of DNA sequence and protein function, QTL analyses, statistics. *Experience in preparing grant applications. *Experience in mentoring technicians, graduate students, or post-docs.
Equal Opportunity Employer: The University of North Carolina at Chapel Hill is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or status as a protected veteran.
Department Contact Name and Title: Samantha Robinson, HR Consultant
Department Contact Telephone Number or Email: [email protected]
Special Instructions for Applicants: