Research Assistant - Cruse Lab
Position Number: 00107192
Primary Function of Organization Unit: The Department of Molecular Biomedical Sciences at the NC State University College of Veterinary Medicine trains doctors of veterinary medicine and graduate students interested in research-based careers focused on the discovery of new knowledge about animal and human health and disease and using those findings to enhance animal and human health and well-being. Students get in depth knowledge of the molecular mechanisms of disease, and experience in the development of new procedures which enable its prevention, diagnosis, and treatment. Our faculty are recognized experts in the fields of cell biology and physiology, cancer biology, developmental biology, environmental science and toxicology, genomics, infectious diseases, neuroscience, pharmacology, radiology, and reproductive biology. Our goals are to advance veterinary medical science through innovative basic and applied research, and by mentoring and inspiring students, providing world-class clinical and diagnostic services, and offering the public the latest knowledge through innovative extension and engagement activities. Our research faculty work in state-of-the-art research facilities including a transgenic mouse facility where graduate students can participate in research projects related to mouse and animal genomics. The Cruse lab, located within the Department of Molecular Biomedical Sciences, is interested in molecular immunology with particular focus on basic and translational research on allergy and inflammation. The mast cell is a critical regulator of allergic inflammation and thus a central focus of research in our lab. We have recently identified a method to specifically target mast cells by modifying gene splicing to eliminate expression of the high affinity IgE receptor on the mast cell surface, resulting in mast cells that are unresponsive to allergens. In addition to developing this therapeutic approach, our research goals include identifying other novel therapeutic targets and developing more effective treatments of allergic diseases, which have an unmet clinical need.
Essential Job Duties: The successful candidate for this role can apply basic molecular biology techniques to assist in furthering the lab's research with the molecular mechanisms that trigger and promote allergic inflammation. The incumbent will assist with the lab's study of mechanisms of activation and phosphorylation of different receptors in immune cells, and help in determining how they differ in signal transduction and protein trafficking pathways that regulate cytoskeletal reorganization and ionic conductance. More specifically, the incumbent will support, develop, design, or execute fundamental research activities associated with the lab's work on molecular immunology with a particular focus on basic and translational research on allergy and inflammation. To that end, they are expected to work independently on collection of data amassed by the lab and effectively analyze research results associated with the lab's findings. Additionally, the incumbent will participate in formulating research methods and suggests options for improving quality and recommending solutions relative to the lab's work on identifying novel therapeutic targets and developing more effective treatments of allergic diseases under the general guidance of the principal investigator. The incumbent may contribute to research publications, reports and draft manuscripts. This position is expected to last one year and its continuation beyond that timeframe will be subject to available funding.
Minimum Education/Experience: Relevant Master's degree, or relevant Bachelor's and 3 or more years of relevant experience, or relevant independent experience and education.
Department Required Skills: N/A
Preferred Experience, Skills, Training/Education: General knowledge of molecular immunology with particular focus on basic and translational research on allergy and inflammation and mast cells as a regulator of allergic information.
Necessary Licenses and Certifications: N/A
AA/EOE: NC State University is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, national origin, religion, sex, gender identity, age, sexual orientation, genetic information, status as an individual with a disability, or status as a protected veteran.
Individuals with disabilities requiring disability-related accommodations in the application and interview process, please call 919-515-3148. Final candidates are subject to criminal & sex offender background checks. Some vacancies also require credit or motor vehicle checks. If highest degree is from an institution outside of the U.S., final candidates are required to have their degree verified at "www.wes.org":http//wes.org. Degree must be obtained prior to start date.
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