Hyde Park Campus
About the Unit
The Senior Bioinformatician will take a lead role as the primary bioinformatics and scientific resource to support project work that solves complex problems. Works at a high technical level in all phases of data management and bioinformatics support activities. Highly complex data will be analyzed by applying sound statistical and commonly accepted bioinformatics methods on a collaborative project team. He/She will be responsible for managing and administering large experimental and clinical data, including installation, operation, and administration of IT infrastructure as well as management of accompanying administrative and regulatory responsibilities. Ensures projects are managed in a timely and efficient manner and are appropriately documented. Work will be done with an interdisciplinary team and will engage with the biomedical informatics community at large on infrastructure, workflow, and pipeline development.
- Apply state-of-the-art computational biology and bioinformatics methods and tools to generate new or validate existing testable hypotheses from complex and large biological datasets.
- Lead the analysis of data resulting in a better understanding of human genetic variation and the association of medical information to uncover gene-disease links and new targets.
- Work effectively with the faculty, clinicians, researchers and experimentalists, to implement novel or adapt existing approaches to optimize upstream and downstream analysis and interpretation of biological data.
- Integrate diverse and heterogeneous datasets, to facilitate mining statistical analysis and visualizations leading to a better understanding of disease mechanisms, and the correlation between phenotype and genotype in different research projects.
- Instruct others in the selection and use of bioinformatics tools.
- Lead the development of new software applications and databases, or the customization of existing applications and databases to meet specific scientific project needs.
- Identify suitable datasets and methods to answer particular research questions.
- Design and perform formal evaluation of informatics methods and products.
- Perform data analyst functions that generate knowledge via data mining, visualization, or other analytics.
- Lead and conduct validation and user acceptance testing.
- Create novel computational approaches.
- Design best research and development practice.
- Stay up-to-date on new advances and developments in bioinformatics and provide on-demand bioinformatics and statistics support to various teams.
- Lead the development of training, tools, and process documentation.
- Other duties as assigned.
- Advanced knowledge of research techniques or methods required.
- Ability to train others required.
- Knowledge of development, optimization, automation, and operations support of analysis pipelines for high dimensional data including whole-genome, whole-exome, and RNA sequencing data required.
- Ability to employ high performance computing to solve parallelizable computer problems required.
- Server and database administration ability required.
- Familiarity with regulations governing management of sensitive information strongly preferred.
Education and Experience:
- Bachelor's degree and five years of relevant experience required;
Master's degree required and three years of relevant experience required;
PhD in Bioinformatics, Computational Biology, Computer Science, Mathematics, or a related field required.
- Degrees in Bioinformatics, Computational Biology, Computer Science, Mathematics or a related field preferred.
- One year of experience in programming for bioinformatics with scripting languages such as Perl, Python, R, Java, XML, C/C++ or SQL required.
- Experience organizing and working with big data required.
- Experience with next generation sequencing technologies such as BWA, Novoalign, STAR, GATK, samtools, Picard or other tools required.
- Experience and proficiency in analysis pipeline development of high throughput data required.
- Cover Letter
NOTE: When applying, all required documents MUST be uploaded under the Resume/CV section of the application
Depends on Qualifications
Scheduled Weekly Hours
Job is Exempt?
Drug Test Required?
Does this position require incumbent to operate a vehicle on the job?
Health Screen Required?
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