University of Colorado - School of Medicine
The laboratory of Dr. Srinivas Ramachandran seeks to hire a Postdoctoral Fellow to work on leading edge questions in chromatin biology pursued as part of our research program outlined below. Our lab is in the Department of Biochemistry and Molecular Genetics at the University of Colorado School of Medicine.
Regulation of genome access underlies growth, development, differentiation, and disease states including tumor initiation. Genome access is regulated by dynamic chromatin landscapes. The long-term goal of the Ramachandran Lab is to understand how distinctive chromatin landscapes that reflect cellular identity are established and maintained. We want to uncover fundamental mechanisms that shape chromatin landscapes by mapping chromatin structure at high temporal and spatial resolution using new experimental and/or computational methods. This research program in chromatin biology will be at the intersection of genomics, biochemistry, and structural biology.
Candidates will be expected to plan and execute independent work, write and submit fellowship applications (if applicable), assist in the writing and publication of experimental results, and contribute positively towards the atmosphere and culture of the lab.
Specific Position Duties with Percentages of Time
The overall goal of the work is to map chromatin structure at high spatial and/or temporal resolution in cells. The techniques that the lab uses towards this program include Drosophila and mammalian cell culture, chromatin biochemistry, nucleic acid purification and sequencing, computational biology, genome engineering, and molecular genetics. Familiarity with standard bioinformatic tools and the ability to design and write custom software (preferably in Python and/or R) are preferred but not required. However, the candidate will be expected to put effort towards gaining these skills during the course of their research.
The candidate will also assist in the preparation of manuscripts to publish their work, the preparation of grant applications, both internal and external, and the preparation of scientific data for presentation at various meetings and conferences. The candidate will also mentor junior scientists in the lab in their scientific development.
The candidate will contribute to research involving one or more of the following:
- Molecular biology and biochemistry experiments
- Cell culture involving immortalized Drosophila/mammalian cell lines
- Nucleic acid isolation and purification
- Generation of next-generation sequencing libraries
- Crosslinking and immunoprecipitation followed by high-throughput sequencing (ChIP-seq)
- Genome engineering using CRISPR-Cas9
The successful candidate is expected to be highly motivated, have ample scientific curiosity, have strong interpersonal skills, and be able to contribute in a positive manner to the collegial atmosphere of the laboratory and the department. The candidate will be expected to direct independent research, mentor more junior lab members, and apply for independent fellowship funding.
- PhD in biology-related field
- Strong record of productivity as evidenced by peer-reviewed publications in internationally recognized English language journals
- Excellent communication skills in the English language
- Experience in molecular biology and cell culture techniques
- Experience in computational biology techniques, including the generation of custom software, is preferred but not required
Salary and Benefits:
Salary is commensurate with skills and experience. The University of Colorado offers a full benefits package. Information on University benefits programs, including eligibility, is located at Employee Services.
The University of Colorado Denver is dedicated to ensuring a safe and secure environment for our faculty, staff, students and visitors. To assist in achieving that goal, we conduct background investigations for all prospective employees.
The University of Colorado strongly supports the principle of diversity. We encourage applications from women, ethnic minorities, persons with disabilities and all veterans. The University of Colorado is committed to diversity and equality in education and employment.
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Application Materials Required:Resume/CV, List of References, Statement of Research Philosophy, Additional Attachments - Refer to Application Materials Instructions Below
Application Materials Instructions:Applications must contain the following and be submitted electronically via CUCareers • Curriculum vitae • Statement of past research (one page) • Statement of your interest in the lab's research program and your long term plans (one page). • Contact information for three references • Start date availability
Job Category: Faculty
Primary Location: Aurora
Department: H0001 -- Anschutz Medical Campus - 20085 - SOM-BioChem&Molecular Genetics
Posting Date: Jan 10, 2018
Closing Date: Ongoing
Posting Contact Name: Srinivas Ramachandran
Posting Contact Email: Srinivas.Ramachandran@ucdenver.edu
Position Number: 00742330