Research Assistant I

Location
East Lansing MI, MI
Posted
Jun 13, 2018
Institution Type
Four-Year Institution
Position Summary

Newly created Precision Health Program at Michigan State University (Director: Anna Moore, Ph.D)  is seeking a Research Assistant I to be a key part of our research team. The translational research focus of our lab requires the use of rodent models, both mice and rats, to study physiological and pathological processes in cancer and diabetes, with particular interest in disease prevention and treatment. We use genetic and transplantable cancer models for studies on prophylactic prevention by epithelial ablation and/or on cancer progression and metastasis with an emphasis on compartment-specific microRNA-based therapeutic intervention. We conduct work on various aspects of cancer pathophysiology including molecular biology and cellular biology studies to identify microRNA functions and targets, genetic engineering of animal models to assess microRNA role within specific cellular compartments of tumor microenvironment, and molecular pathology with innovative human tissue-based multiplex ISH/IHC assays to implement diagnostics applications of microRNA biomarkers in a in clinical setting. We also use models of diabetes and pancreatic islet transplantation and working on protection of insulin-secreting cells from autoimmune destruction during the disease progression. One of the main tool in our research is the use of non-invasive in vivo imaging including magnetic resonance imaging, optical/bioluminescence imaging and PET imaging. The main responsibilities of the Research Assistant I will be to conduct in vivo procedures on these rodent models, and preparatory work and related in vitro experiments. The candidate is also expected to assist PI in overseeing and conducting laboratory research, and in writing manuscripts and grant proposals.

Work in the laboratory on various aspects of the pathophysiology of cancer is multi-disciplinary, including molecular biology and cellular biology studies to identify microRNA functions and targets, to genetic engineering of animal models to assess microRNA role within specific cellular compartments of tumor microenvironment, and molecular pathology with innovative human tissue-based multiplex ISH/IHC assays to implement diagnostics applications of microRNA biomarkers in a in clinical setting.

This is an off-dated position funded for one year from the date of hire with possible extension contingent upon funding renewal.

Unit Specific Education/Experience/Skills

Knowledge equivalent to that which normally would be acquired by completing a four-year college degree program in the specific field of research employment or other related science fields; one to three years of related and progressively more responsible or expansive work experience in standard laboratory procedures and safety requirements and performing analytical and research techniques in an area related to research being performed; may require software specific to the area of research; or an equivalent combination of education and experience. The position may require special licensing or certification in the field related to the area of employment.

Desired Qualifications

• Master’s degree in a related discipline with relevant lab experience (preferably 3-5 years).
• Experience working with rodents (mice and/or rats) and proficiency in common surgical and non-surgical procedures is required.
• Knowledge of cell culture, and basic knowledge of molecular biology, molecular pathology, cell biology and/or cancer biology is a must.
• Experience with injection procedures such as intravenous, intraperitoneal, intraductal mammary gland and intrapancreatic and/or in vivo viral delivery (e.g., Adeno-Cre), intrasplenic is a plus. Training will be provided as needed to master these procedures, which are a fundamental components of this position.
• Experience working with larger animal models (e.g., companion animals, pig, sheep) is a plus.
• Familiarity with in vivo imaging (MRI, optical/bioluminescence, PET) is a plus.
• Excellent oral and written communication skills are required.
• Excellent organizational skills are required.
• Ability to work independently and in a team environment.

Required Application Materials

Please submit a cover letter outlining your research background and research interests, a recent Curriculum Vitae, and names and contact information for three references.

Special Instructions

For more information, please visit http://www.rad.msu.edu/

Work Hours

STANDARD 8-5

Description of End Date

This is an off-dated position funded for one year from the date of hire with possible extension contingent upon funding renewal.

Summary of Health Risks

-Exposure to human blood, serum, tissue, and other body fluids; and materials covered under Universal Precautions

-Work with animals or unfixed animal tissue

Bidding Eligibility ends on 06/19/2018 at 11:55 PM

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