Research Associate-Fixed Term

Location
East Lansing MI, MI
Posted
Jun 13, 2018
Position Type
Postdoc
Institution Type
Four-Year Institution
Position Summary

A research associate (postdoctoral researcher) position in structural biology/biochemistry is immediately available in the laboratories of Dr. Jian Hu (Department of Biochemistry & Molecular Biology) and Dr. Robert Hausinger (Department of Microbiology & Molecular Genetics).

The laboratories are characterizing the structures and mechanisms of four enzymes associated with the Lar Operon (LarA/B/C/E).  The lactate racemase LarA contains a recently discovered organometallic nickel-pincer cofactor (Science 2015, 349:66), which is sequentially synthesized by the other three Lar proteins (PNAS 2016, 113:5598, PNAS 2017, 114:9074).  The research associate will work in both laboratories with a focus on structural characterization of the Lar proteins, primarily by X-ray crystallography with the opportunity to also use cryo-EM, while investigating the enzymes by using other biochemical/biophysical methods.  The cryo-EM facility will be updated with a Talos Arctica 200 kV FEG Transmission and Scanning Transmission Electron Microscope by the end of 2018.  This highly productive project has been funded by NSF since 2015 and renewed recently for another three years of support until 2021. 

To obtain more detailed information, please visit our websites (Hu lab:  https://bmb.natsci.msu.edu/faculty/jian-hu/current-research/ ; Hausinger lab:  https://mmg.natsci.msu.edu/people/faculty/hausinger-robert-p/ ). 

The position will initially be available for one year with possible renewal based on mutual satisfaction.

Required Degree

Doctorate -Biochemistry, Biophysics, Molecular Biol

Minimum Requirements
  • A doctorate degree in Biochemistry, Biophysics, Molecular Biology or related field.
  • The successful candidate must be highly self-motivated; 
  • Have hands-on experience in protein expression/purification and structure determination using X-ray crystallography.
Desired Qualifications

Experience in cryo-EM is desired.

Required Application Materials
  • Brief cover letter
  • CV
  • Names and contact information of three references.
Special Instructions

Department website: https://bmb.natsci.msu.edu/

Website

https://bmb.natsci.msu.edu/

MSU Statement

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