I. DEPARTMENT INFORMATION
Job Description Summary:
The Department of Biochemistry and Molecular Medicine (BMM) strives to deliver the highest quality of professional education and training, and conduct cutting edge research in the areas of biochemistry, molecular genetics and genomics with a goal to better understand human disease. Additionally, the department continues to have a long and successful record in training undergraduate, master and graduate students at the George Washington University School of Medicine and Health Sciences.
Our Research Programs span from cancer biology, hepatobiology, autism, vascular biology, and computational genomics. Unlocking the mysteries of biologic processes at the molecular and genomic level is the common thread connecting all research programs. The overall research in the department continues to connect modern biochemistry and genomic discoveries to translational medicine, leading to a unique multidisciplinary research program in biochemistry and molecular medicine. Find out more here: https://smhs.gwu.edu/biochemistry/
The Biochemistry and Molecular Medicine department is looking for a candidate that will work under the direct supervision of Dr. Mei-Yi Wu. He or she will be responsible for carrying out the research experiments. He or she will also participate in the weekly lab meeting, and present and discuss the progress of the project with Dr. Mei-Yi Wu.
The project focuses on two epigenetic modulators and members of the AT-rich interaction domain family, ARID4A and ARID4B. Epigenetics plays an important role in human health and disease. Disruption of epigenetic modifications leads to dysregulation of gene function without altering the DNA sequence per se. A major challenge in understanding the importance of epigenetics in human health and diseases is to identify the specific epigenetic factors and the signaling involved. Currently, we are investigating the role of ARID4A and ARID4B in development and cancer disease using state-of-the-art conditional knockout mouse models and genomic and proteomic approach. We also study the role of ARID4B in cancer stem cells that have been suggested as the major cause for therapy resistance and the driving force behind cancer metastasis and relapse. To investigate whether and how ARID4B drive cancer development, we evalute the underlying molecular mechanisms by which ARID4B promotes therapy resistance and aggressive cancer.
-Culture and transfection of mammial cells
-Collecting samples for reporter gene assays
-Western blooting to analyze protein expression
-Cancer cell migration and invasion assays
-Human cancer xenogrant experiments using SCID/NOD mice
-The postdoc will also work with genetically modified mice
-Ordering lab supplies, lab maintenance and other duties as assigned
-This position performs other duties as assigned. The omission of specific duties does not preclude the supervisor from assigning duties that are logically related to the position.
Qualified candidates will hold a PhD in a related discipline. Degree must be conferred by the start date of the positionAdditional Required Licenses/Certifications/Posting Specific Minimum Qualifications: Preferred Qualifications:
Ph.D. degree, with experience in molecular and cellular biology.
I. POSITION INFORMATION
Campus Location: Foggy Bottom, Washington, D.C. College/School/Department: School of Medicine and Health Sciences (SMHS) Family Research and Labs Sub-Family Laboratory Research Stream Individual Contributor Level Level 3 Full-Time/Part-Time: Full-Time Hours Per Week: 40 hours per week Work Schedule: Monday through Friday, 9:00 - 5:30 Position Designation: Essential: Employees who perform functions that have been deemed essential to maintaining business or academic operations. Employees are generally expected to work from home during an event and may be asked to physically report to work. Telework: Required Background Check Criminal History Screening, Education/Degree/Certifications Verification, Social Security Number Trace, and Sex Offender Registry Search Special Instructions to Applicants: Internal Applicants Only? No Posting Number: R000448 Job Open Date: 01/11/2018 Job Close Date: If temporary, grant funded or limited term appointment, position funded until: Background Screening Successful Completion of a Background Screening will be required as a condition of hire. EEO Statement:
The university is an Equal Employment Opportunity/Affirmative Action employer that does not unlawfully discriminate in any of its programs or activities on the basis of race, color, religion, sex, national origin, age, disability, veteran status, sexual orientation, gender identity or expression, or on any other basis prohibited by applicable law.
Posting Specific Questions
Required fields are indicated with an asterisk (*).
- Curriculum Vitae
- Cover Letter
- Letter of Recommendation 1
- Letter of Recommendation 2
- Letter of Recommendation 3