Hyde Park Campus
About the Unit
The Section of Genetic Medicine continues to shape the future of personalized medicine with successful research programs focused on the quantitative genetic and genomic science. The Section provides extremely valuable collaborations with investigators in the Department of Medicine who are seeking to develop new and more powerful ways to identify genetic risk factors for common, complex disorders with almost immediate clinical application. The Section of Genetic Medicine conducts impactful investigations focused on quantitative genetics, systems biology and genomics, bioinformatics and computational biology. Some highlights from the past year include: Demonstrated that RNA splicing is a primary link between genetic variation and disease ( Li, Gilad, et al, Science , 2016) Developed multi-tissue imputation methods to impute gene expression in uncollected or inaccessible tissues to enhance the identification of biomarkers for complex diseases and traits and facilitate the development of precision medicine (Wang, Stranger, Im, Nicolae, et al, American Journal of Human Genetics, 2016) Developed a gene based association method for known and new genes associated with disease traits and provided insights into the mechanism of these associations (Im et al, Nature Genetics, 2015) Developed a new gene based association method for mapping traits using reference transcriptome data that detected known and new genes associated with disease traits and provided insights into the mechanism of these associations. (Im, Nicolae, GTEx Consortium, et al, Nature Genetics, 2015).
Principal contribution is the application of principles and knowledge relevant to the administration and support of the research project. Under limited direction, the Lab Manager performs complex lab and/or research-related duties and tasks. Helps develop, design and conduct research projects according to plan, including planning new procedures, adapting existing procedures to the needs of the project, and making contributions to methodology.
- Manage, maintain, and ensure laboratory compliance to the human subjects (IRB), biosafety (IBC), and animal usage (IACUC) protocols.
- Ensure adherence to safe laboratory practices, proper upkeep of the laboratory environment and equipment, participation in laboratory meetings and functions.
- Provide logistical support for the smooth running of the lab including ordering, organization, and stocking.
- Provide administrative support to the principal investigator and to the laboratory for mailing/shipping, organizing events, other tasks as required.
- Perform experiments to characterize the genetic basis of inter-individual variation in immune responses to infectious agents.
- Generation of induced pluripotent stem cells, (iPSCs), the derivation of iPSCs into macrophages, the infection of iPSC-derived macrophages with level 2 infectious agents (e.g., Salmonella and flu viruses), and the generation of RNA-seq and ATAC-seq libraries from non-infected and infected cells.
- Knowledge in relevant scientific field required.
- Knowledge of research techniques or methods required.
- Knowledge of regulatory policies and procedures required.
- Analytical skills required.
- Problem-solving skills required.
- Attention to detail required.
- Organizational skills required.
- Verbal and written communication skills required.
- Ability to work independently and as part of a team required.
- Knowledge of Microsoft Office required.
- Ability to train others required.
Education and Experience:
- Bachelor's degree in a field relevant to the research being conducted required.
- 5 years of relevant research experience required.
- Cover Letter
NOTE: When applying, all required documents MUST be uploaded under the Resume/CV section of the application
Depends on Qualification
Scheduled Weekly Hours
Job is Exempt?
Drug Test Required?
Does this position require incumbent to operate a vehicle on the job?
Health Screen Required?
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