Job description

Duties: This position will serve as Director of the Solid Tumor Immunotherapy Laboratory (STIL), a research laboratory in the Center for Cellular Immunotherapies (CCI) and report directly to the Director of CCI, and work closely with the Director of Research Operations.

The Director of STIL will be responsible for establishing and leading a cancer biology team focused on proof-of-concept, optimization and preclinical development with the goal of advancing cellular therapies for solid tumors into the clinic. Emphasis will be the generation of innovative cancer treatment strategies involving T cells and their impact on the immune response, tumor biology and the tissue/tumor microenvironment in the setting of translatable preclinical studies. More specifically, projects directed by this individual will focus on using in vitro platforms and specialized animal systems (e.g., orthotopic transplantation tumor models) to: 1) understand the factors and mechanisms associated with successful adoptive transfer of immune T cells and improving the outcomes of both endogenous and gene-modified T cells; 2) develop mechanism-based strategies to improve the survival, expansion and potency of infused T-cell products directed against solid tumors; 3) devise methods to modulate the host immune environment to optimally activate T cells in humans and 4) design and implement strategies to evaluate on-target, off-tumor toxicity of genetically-modified immune cells. In addition, the STIL Director will be involved in carrying out mechanism of action investigations, biomarker identification, generation of data that supports patient stratification, and the pharmacodynamic assessment of cellular therapies in pre-clinical and clinical settings. The successful candidate will supervise laboratory-based experiments to help translate novel therapeutic approaches into research plans with near- and long-term goals.

The STIL Director will ensure the timely planning and execution of research projects, including the preparation of reports, presentations, and scientific papers. He or she will be required to monitor progress and timelines related to translational research projects and provide regular updates to the CCI Director and Director of Research Operations. He or she will manage internal and external collaborations, including academic and industrial partners. The Director of STIL will ensure continuation of collaborative projects and engage in direct communication with other Principal Investigators as necessary. Maintaining an understanding of emerging concepts in the immunotherapy field is therefore required. He/she will be responsible for the effective communication of results/findings to translational science operations teams and other groups in CCI for IND-enabling activities.

This individual will assist the CCI Director in strategic development and plans leading to the discovery and clinical translation of new cellular immunotherapies for solid tumor indications. This individual will participate in writing and assembling grant applications as well as related reports. These efforts will support ongoing and new projects to broaden the translational research base as it relates to the mission of CCI. The STIL Director will present data at local, national and international meetings.

Qualifications: * The minimum of a Master's degree and 5 to 7 years of relevant experience in immunology and/or cancer research; Ph.D. in immunology or related discipline strongly preferred.
* Demonstrated expertise with tools and analytics used in cancer immunotherapy research;
* Excellent written and interpersonal communication skills;
* Strong background and publication record in the areas of human T cell immunology and cancer biology;
* Proven scientific/leadership expertise (lead by example, balance leadership strength with self-awareness);
* Prior experience with managing complicated research projects involving multiple sub-teams of researchers;
* Ability to develop and maintain multiple internal and external relationships regarding research;
* Prior experience working in large, complex organizations such as the University of Pennsylvania;
* Build long-term, productive relationships by creating a culture of inclusion, engagement and dialogue;
* Strong experience working on research teams and directly participating in research studies;
* Exhibit a great attitude as a team player who excels in a demanding environment;
* Strong multitasking abilities and an extremely high-level of reliability and dependability;
* Results-oriented, establish clear expectations, priorities and goals;
* Use good judgment and problem-solving logic;
* Self-starter with a strong desire to contribute to the programmatic mission.

Reference Number: 40-28233

Salary Grade: 029

Employment Type: Exempt

Org: CI-Center for Cellular Immunotherapy

Special Requirements:

Job Family: B-Executive/Managerial Administration




Diversity Profile: University



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Job No:
Posted: 3/20/2018
Application Due: 11/4/2019
Work Type: