HIGH-THROUGHPUT SCREENING CORE PROJECT MANAGER
Duties: We are seeking a highly motivated and experienced Project Manager to join our research team, and work in the UPENN High-throughput Screening Core (HTSC). The primary mission of the HTSC is to provide the PSOM community with high-throughput screening capabilities to identify genes or organic small molecule modulators of signaling pathways, cellular phenotypes, and protein function in models of human disease.
The successful candidate will be expected to take a leadership role to independently manage high-throughput screening projects, train and supervise technical staff in the core. These responsibilities will include the de novo design, optimization, and validation of diverse cell based assays for high-throughput genetic/chemical screens. These assays will include complex to advanced procedures in molecular biology, and mammalian cell biology, including use of primary cells and iPSC models. A specific focus will be on high-content/phenotypic assay development in high-density formats (i.e. 384 well microtiter plates), growth and development of non-arrayed shRNA/CRISPR screens, and creation of computational pipelines to analyze and interpret data from these assays, including Next-Generation sequencing data. He/she must be able to identify and resolve technical problems, and use analytical and decision-making skills to implement and troubleshoot projects. The candidate will be required to execute validated high-throughput chemical and genetic (i.e. siRNA, shRNA, CRISPR, cDNA) screening experiments, including the operation of laboratory robotics and screening library management. He/she will also be responsible for creating advanced analyses and reports of large data sets to be presented to the Scientific and Technical Directors.
Responsibilities include serving as a liaison between the Directors (Scientific and Technical) and the rest of the team (including other investigators, staff, and other internal and external entities), managing and monitoring operations and timelines, and supervising operational staff. Proactively identify and prioritize Core opportunities and risks. Tasks include designing and managing in vitro-high throughput screening experiments, advise the Directors on new services and develop new services, providing quotes to investigators for core services and assign to staff as appropriate, negotiating changes to projects as needed, advising on research approaches and methodology, managing project workflows, advise the Scientific and Technical directors on fee structure and preparation of annual budgets.
Qualifications: A highly motivated individual with the minimum of a Masters degree in biologically relevant area and 3 to 5 years of direct experience in assay development and high-throughput screening and the defined duties, or an equivalent combination of education and experience, required. PhD is a plus. The ideal candidate will have strong organizational skills, effective communication skills; the ability to work as an effective member of a team, and independently oversee initiation and completion of intermediate to complex, long-range tasks.
Reference Number: 40-28138
Salary Grade: 028
Employment Type: Exempt
Job Family: I-Technical/Professional Research