Research Specialist 3
Hyde Park Campus
About the Unit
The Section of Transplantation is built on a strong history of surgical excellence, including the first-ever animal organ transplant in 1904. Over the years, the section has gone on to achieve many more firsts, including the first successful living-donor liver transplant and the first heart-liver-kidney transplant in the world. Today, the University of Chicago Medicine is home to one of the busiest organ transplant centers in the nation and offers more transplant options than any other program in Illinois. What our surgeons can achieve in the operating room would not be possible without the ongoing work that is done in our laboratories, and this is especially true in the Section of Transplantation. Our researchers are well known for their basic science research in transplantation tolerance and clinical trial work around islet cell transplantation for diabetes.
The Research Specialist 3 in the Islet and Immune Cell Therapy Laboratory will be responsible for making technical contribution to the ongoing projects in the lab based on background in laboratory working and various laboratory techniques. The main focus of the work will be development and performance of sterilization process of the equipment used for islet isolation and other processes ongoing in the lab in accordance with current Good Manufacturing Practice (cGMP) guidelines. That will include development and continuous improvements of Standard Operating Procedures (SOPs) for these processes and preparation of the necessary documents regarding this process for the purpose of the Biological License Application to FDA. Will take part in islet isolation process or other processes performed in the clean room facility. That requires work time flexibility, being available on-call, 24/7. The Research Specialist 3 will be also responsible for establishment and maintenance of the laboratory inventory system, keeping inventory up to date and preparation inventory reports to be reviewed by Lab Manager/Technical Director. Another duties include performance of quality assays required for products release accordingly to established procedures and providing feedback regarding possible improvements in these processes, maintenance of the laboratory equipment including calibration, troubleshooting, preventive maintenance testing, contribute expertise in small animals techniques and survival surgeries, being responsible of laboratory preparation to theses procedures, keeping laboratory in the condition that fulfills IACUC requirements, training new staff in these procedures. This person will be responsible also for keeping the laboratory up to date with new available technologies and equipment that could improve the lab work, development of proficient knowledge about the equipment used in the lab, training new personnel in the use of the equipment and providing help in description of laboratory materials and methods to manuscripts and grant proposals.
80% Facilitate/contribute to clinical activities of the laboratory
- Develop and implement sterilization techniques of the equipment and items
- Prepare and update Standard Operating Procedures and other documentation required for equipment sterilization
- Train and supervise new staff in sterilization techniques
- Develop and implement inventory system for cGMP facility
- Create report system for inventory
- Perform and improve Quality Control testing of islet and other products produced in clinical-grade processes with the input in designing the assay, choosing the appropriate laboratory techniques, preparation of required documentation
- Prepare, maintain and troubleshoot equipment used in clinical-grade process
- Review accuracy of Master Production Batch Records
- Prepare reports to Technical Director/Lab Manager regarding cGMP facility preparation status for clinical-grade processes
20% Facilitate/contribute to research activities of the laboratory:
- Contributes to the research projects/programs being conducted in the laboratory with specific skills from an extensive, demonstrated background and technical expertise in molecular and cell biology
- Is fully responsible for laboratory housekeeping, including equipment maintenance, laboratory inventory, including system for purchase ordering, checking the invoices, assuring the laboratory compliance with safety regulations
- Provide technical expertise in ongoing and new projects, help in choosing appropriate laboratory techniques, equipment and reagents for new projects
- Train new staff in laboratory techniques, laboratory policies and regulations
- Responsible in keeping laboratory up-to-date with new techniques
- Help in data analysis, description of laboratory materials and methods to manuscripts and grant proposal
- Laboratory skills: pipetting, buffer/reagents preparation, proficient in laboratory equipment use required
- Proficient skills in mammalian cell culture procedures and associate aseptic techniques required
- Knowledge of cGMP/cGMP regulations related to laboratory work
- Knowledge of laboratory regulatory policies and procedures required
- Knowledge of sterilization techniques required
- Experience in laboratory inventory systems required
- Problem-solving skills required
- Organizational skills and attention to detail required
- Verbal and written communication skills required
- Analytical skills required
- Excellent interpersonal skills with the ability to work well with others in a dynamic highly collaborative environment and independently required
- Knowledge of Microsoft Office package required
- Ability to train others required
- Expertise in sterilization techniques accordingly to cGMP and FDA standards preferred
- Experience in ELISA assay, endotoxin LAL assay, fluorescence microscopy preferred
Education, Experience and Certifications:
- Master's degree required in the field of biological sciences from the accredited program required
- A minimum of 8 years of laboratory experience in the field of cell biology, cell therapy or other related required
- A minimum of 5 years of experience in laboratory work accordingly to current Good Manufacturing and Laboratory Practice (cGMP/cGMP) regulations required
- Experience in development and implementation of Standard Operation Procedures (SOPs) in laboratory work required
(NOTE: When applying, all required documents MUST be uploaded under the Resume/CV section of the application.)
- Cover letter
Depends on Qualification
Scheduled Weekly Hours
Job is Exempt?
Drug Test Required?
Does this position require incumbent to operate a vehicle on the job?
Health Screen Required?
Background Check Required?
Remove from Posting On or Before
The University of Chicago is an Affirmative Action/Equal Opportunity/Disabled/Veterans Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national or ethnic origin, age, status as an individual with a disability, protected veteran status, genetic information, or other protected classes under the law. For additional information please see the University's Notice of Nondiscrimination.
Staff Job seekers in need of a reasonable accommodation to complete the application process should call 773-702-5800 or submit a request via Applicant Inquiry Form.
The University of Chicago's Annual Security & Fire Safety Report (Report) provides information about University offices and programs that provide safety support, crime and fire statistics, emergency response and communications plans, and other policies and information. The Report can be accessed online at: http://securityreport.uchicago.edu. Paper copies of the Report are available, upon request, from the University of Chicago Police Department, 850 E. 61st Street, Chicago, IL 60637.
The University of Chicago is an urban research university that has driven new ways of thinking since 1890. Our commitment to free and open inquiry draws inspired scholars to our global campuses, where ideas are born that challenge and change the world.
We empower individuals to challenge conventional thinking in pursuit of original ideas. Students in the College develop critical, analytic, and writing skills in our rigorous, interdisciplinary core curriculum. Through graduate programs, students test their ideas with UChicago scholars, and become the next generation of leaders in academia, industry, nonprofits, and government.
To learn more about the university click here http://www.uchicago.edu/