Research Associate in Molecular Signaling and Immunology
Working Title: Research Associate in Molecular Signaling and Immunology
Position Type: Professional Research Staff
Department: Department of Pathology, Research
Posting Date: 09-21-2017
The Department of Pathology at the University of Virginia seeks a Postdoctoral Research Associate position in the laboratory of Dr. Chance John Luckey, MD PhD. We are looking for a talented and self-motivated individual who is interested in joining a growing team focused on understanding the molecular regulation of immune memory, with a specific focus on understanding how different cytokine signals drive the epigenetic, transcriptional and splicing programs that regulate memory lymphocyte self-renewal.
A key feature of our immune response is its ability to remember previous exposures and respond more rapidly upon re-challenge. Indeed, memory immune responses serve as the basis for successful vaccination. One key attribute of memory lymphocytes is their ability to undergo homeostatic self-renewal (Luckey et al PNAS 2006, Luckey and Weaver Cell Stem Cell 2012). Two key cytokines that regulate this process in vivo are IL-7 and IL-15. Thus it is not surprising that they play essential roles in several important clinical situations. In patients undergoing stem cell transplant, signals via IL-7 and IL-15 are essential for the reconstitution of the mature peripheral T cell compartment. In T cell based cellular therapies, IL-15 supports the ex vivo culture and expansion of various clinically useful T cell populations such as Chimeric Antigen Receptor bearing T cells. Despite their biological and clinical importance, the underlying molecular mechanisms for their differential effects remain unclear. Given that IL-7 and IL-15 both signal through the same common gamma chain yet induce very different functional outcomes, we have applied novel large-scale proteomic and phospho-proteomic approaches (Lu et al Cell Stem Cell 2014, Zhou et al Nature Communications 2013, Ficarro et al Mol Cell Proteomics 2011, Luckey et al Transfusion 2011) to better understand how IL-7 and IL-15 drive different functional outcomes in both mouse and human memory CD8+ T cells. We have identified several novel signaling pathways that are differentially regulated by IL-7 versus IL-15, and the incumbent will work to further characterize the detailed molecular mechanisms by which these novel pathways control memory lymphocyte function.
Qualified applicants must have an PhD, MD, or MD/PhD and experience with advanced molecular biology and protein biochemistry techniques. Candidates should be capable of designing and carrying out high level, complex research experiments while functioning independently under the general direction of the principal investigator. Candidates with experience with large scale data generation and analysis; in vivo cellular and molecular immunology, human immunology, multi-color flow cytometry, and cytokine signaling; strong writing and communication skills; a willingness to collaborate; and who are eligible for NIH training grants are preferred.
To apply, visit https://jobs.virginia.edu and search on Posting 0621748. Complete a Candidate Profile on-line; attach curriculum vitae, cover letter, contact information for three references and a statement of research interest. The position will remain open until filled.
For further information about the position, please contact Chance John Luckey, MD, via email at [email protected]
For questions regarding the application process, please contact Mary White via email at [email protected] or telephone at 434-924-9712.
The University of Virginia is an equal opportunity/affirmative action employer. Women, minorities, veterans and persons with disabilities are encouraged to apply.
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