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BIOSTATISTICIAN III

Job description


diversity employer



BIOSTATISTICIAN III
Ctr Applied Genomics and Precision Med

Occupational Summary:

Are you a quantitative scientist with a strong interest and background in genomic medicine? The Center for Applied Genomics and Precision Medicine (CAGPM) at Duke University would like you to join our interdisciplinary team!

About this role:

As a biostatistician in CAGPM, you will work within applied genomics and precision medicine programs, analyzing high-dimensional genomic and clinical datasets, including clinical survey data, pedigree data, (RNA) sequencing data, microarray data, proteomics data, multiplex PCR data, or other complex 'omic' datasets, and wearable device data. Commonly performed analyses include data normalization, clustering, principal components analysis, hypothesis testing, generalized linear models, feature and model selection, and functional enrichment and pathway analyses.

You will apply state-of-the-art and classical statistical approaches to a variety of clinical datasets to elucidate novel biological information and clinical relevance. The specific clinical areas of interest include family health history and inherited disease risk, infectious disease, cardiovascular events, and pharmacogenomics, with continued expansion to other clinical fields.

The CAGPM is a highly collaborative work environment, and you will interact with physicians, biologists, and quantitative scientists within the applied genomics and precision medicine programs by supporting refinement and interpretation of analytical results from biological and clinical studies and activities destined for publication. You will have opportunities for publication, both in methodological journals as well as relevant medical journals. You will assist the team in developing research results into quality manuscripts for submission to peer-reviewed journals, and may have the opportunity to present your work at relevant scientific meetings or conferences.

You will be an integral member of any team of investigators working on project(s) from which the data is derived.

Responsibilities:

With appropriate guidance, a Biostatistician III is responsible for executing the analytical needs of a project including but not limited to: drafting statistical analysis plans, processing and assessing quality of genetic/genomic/proteomic/metabolomics/EMR/wearable or other clinical data, generating descriptive and basic test statistics, design, implement, and execute statistical models, learn and apply new statistical methods as needed, generate summary reports, present results in verbal form to requestors, and support all phases of manuscript preparation.

The Biostatistician III must adhere to reproducible research principles, and to this end, be well organized, document work thoroughly, and version control code, enabling transition of a project to another team member, potentially after long periods of project inactivity. Additionally, must adhere to standard operating procedures (SOPs) of the functional department as they apply to documentation and validation of clinical research statistics. Understands guidelines from the FDA, ICH, EMEA, NIH, or other regulatory agencies as they apply to statistics and programming expectations for each project. Collaborates closely with investigators, sponsors, and other project leadership to ensure that trial/project results and conclusions are presented accurately and without bias.

The Biostatistician III will contributes meaningfully to discussions of proposed and in progress analyses and identify the next steps for analyses, participate and present in project and team meetings, provide mentorship for other team members, and assist investigators in proposal development. Collaborates effectively with a variety of types of individuals: programmers, statisticians (both junior and senior), students, medical personnel, and representatives within the business community.

Work closely with the data team to understand the study data and any analysis implications arising from how the data was generated or collected, help identify potential data problems from analytic queries and brings them to the attention of the team. Handles and secures highly confidential and sensitive analyses and documentation. Supports the preparation of Data and Safety Monitoring Board reports and final statistical and study reports, including those intended for regulatory submission, and collaborates with medical writers as needed.

Understands the contracted scope of work and forecasts monthly hours expected to complete each trial/project. Creates timelines for statistical project management, with assistance from project leader and statistical managers. Manages project responsibilities with decreasing levels of supervision or regular support and takes initiative to complete project-specific responsibilities with minimal supervision. Demonstrates progress in ability to multi-task.

Perform other related duties incidental to the work described herein.

Preferred Qualifications at this Level
Education/Training: The Biostatistician III position requires a PhD. in biostatistics, bioinformatics, or a related field.

Experience: Requires two years of experience working on collaborative projects involving high-dimensional data such as genomics, proteomics or metabolomics. Experience with next-generation sequence data is a plus.

Job Skill:
  • Exceptional written and oral communication skills and able to communicate effectively with collaborators with varied backgrounds
  • Time management skills - a successful candidate must manage his/her time and prioritize the importance of various projects and meet deliverable deadlines
  • Working knowledge of the following: shell scripting (e.g. Bash), R and python. SAS or similar languages are a plus.
  • Experience with version control (e.g. git) and code documentation.
  • Experience with database querying and programmatic access from R, python or similar languages.

Job Conditions:
Usual office working conditions
The intent of this job description is to provide a representative and level of the types of duties and responsibilities that will be required of positions given this title and shall not be construed as a declaration of the total of the specific duties and responsibilities of any particular position. Employees may be directed to perform job-related tasks other than those specifically presented in this description.

Requisition Number
401379581

Location
Durham

Duke Entity
MEDICAL CENTER

Job Code
2682 BIOSTATISTICIAN III

Job Family Level
74

Exempt/Non-Exempt
Exempt

Full Time / Part Time
FULL TIME

Regular / Temporary
Regular

Shift
First/Day

Minimum Qualifications
Duke University is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex,sexual orientation, or veteran status.
Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas—an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.
Essential Physical Job Functions: Certain jobs at Duke University and Duke University Health System may include essential job functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.

Education

Position requires a minimum of a Doctoral degree in (bio) statistics or related field and no relevant experience, or a Master's degree in (bio)statistics or related field and 2 years relevant experience, or a Bachelor's degree in (bio) statistics or related field and 4 years relevant experience.

Experience

OR AN EQUIVALENT COMBINATION OF RELEVANT EDUCATION AND/OR EXPERIENCE Contribution to analysis of clinical trials and/or clinical research projects, and/or participation in preparation of academic manuscripts or other written summaries of analysis results, thorough experience with SAS, and solid command of the English language is required. Desirable experience includes prior role as a lead statistician on clinical trials and/or clinical research projects that have delivered the agreed-upon end products on time, and prior guidance of lower level or less experienced staff.

Auto req ID

97421BR

Duke University is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, genetic information, gender, gender expression, gender identity, national origin, race, religion, sexual orientation, or veteran status.

Essential Physical Job Functions: Certain jobs at Duke University and Duke University Health System may include essential job functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.

PI101381535

 

 

 

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Job No:
Posted: 2/28/2018
Application Due: 4/29/2018
Work Type:
Salary: