University of Colorado - School of Medicine
Overall Description of Responsibility or Nature of Work
A postdoctoral position is available in the laboratory of Drs. Maranke Koster and Peter Koch at the University of Colorado Anschutz Medical Campus. The overall goal of the project is to investigate the mechanisms that underlie tissue fragility in patients affected by genetic skin disorders known as ectodermal dysplasias. To investigate these mechanisms, the postdoctoral fellow will use and further develop human stem cell-based models that have been established in our laboratory.
Specific Position Duties with Percentages of Time
The successful candidate will use our established methods to generate keratinocytes from our patient-derived induced pluripotent stem cells (iPSC). These keratinocytes will be used to analyze disease mechanisms using cell biological, biochemical, and transcriptome experiments (including RNAseq and ChiPseq). Examples of these experiments include assays to measure proliferation, migration, cell-cell adhesion, and cell-ECM adhesion.
The successful candidate should have extensive experience in cell biological techniques including assays to analyze keratinocyte properties. Further, the successful candidate should have previous experience in transcriptome studies. Candidates with experience in pluripotent stem cell culture and differentiation are preferred.
This research position will be supported by a T32 NIH/NIAMS-funded training grant that aims to prepare postdoctoral fellows for independent scientific careers. As part of this program, the trainee is required to prepare and submit an annual progress report to the NIH. Further, trainees are expected to apply for additional extramural funding (e.g. individual K-award) during their first year of support.
WORKING CONDITIONS: The position requires 100% effort working within the secured research laboratory.
Specific duties include:
- Perform all experiments necessary for the study
- Analyze and interpret data
- Troubleshoot experimental methods
- Summarize data weekly for a weekly discussion
- Make plans for future experiments
- Present data at a national or international conference (at least once a year)
- Prepare research grant proposals and papers
- Supervise and teach students
Applicants must be US citizens or have a green card.
- Graduation from an accredited college or university with a PhD in Cell Biology, Molecular Biology, or a similar field.
- Minimum of 3 year(s) research experience in a cell biological laboratory
- Prior successful working experience using a wide range of cellular biology techniques and protein biochemistry techniques.
- Comfortable using mice as a model system
- Excellent communication skills using the English language.
- The ability to work independently within the research laboratory.
- Experience in working with keratinocyte cultures or stem cell cultures.
Salary and Benefits:
Salary is commensurate with skills and experience. The University of Colorado offers a full benefits package. Information on University benefits programs, including eligibility, is located at Employee Services.
The University of Colorado Denver is dedicated to ensuring a safe and secure environment for our faculty, staff, students and visitors. To assist in achieving that goal, we conduct background investigations for all prospective employees.
The University of Colorado strongly supports the principle of diversity. We encourage applications from women, ethnic minorities, persons with disabilities and all veterans. The University of Colorado is committed to diversity and equality in education and employment.
The Immigration Reform and Control Act requires that verification of employment eligibility be documented for all new employees by the end of the third day of work. Alternative formats of this ad are available upon request for persons with disabilities.
Application Materials Required:Cover Letter, Resume/CV, List of References
Application Materials Instructions:
Applications are accepted electronically at CU Careers, refer to requisition ID: 12077
When applying, applicants must include:
- A letter of application which specifically addresses the job requirements and outlines qualifications
- A current Resume/CV
- The names, addresses, daytime telephone numbers and e-mail addresses for three professional references, either attached to your resume/CV or uploaded as a separate document
Please do not submit any of your application material (via email) to the job posting contact.
Job Category: Faculty
Primary Location: Aurora
Department: H0001 -- Anschutz Medical Campus - 20143 - SOM-Dermatology
Posting Date: Dec 13, 2017
Closing Date: Ongoing
Posting Contact Name: Maranke Koster
Posting Contact Email: [email protected]
Position Number: 00644505