Postdoctoral Scholar - Bota Laboratory

Job description

University of California, Irvine

Postdoctoral Scholar - Bota Laboratory

Recruitment Period Open February 12th, 2018 through June 30th, 2018 Description

The Postdoctoral Scholar, Neurology will have a strong background and publication record in cellular or molecular biology of cancer, with a preference for expertise in proteasome biology. The applicant will be able to design and execute a variety of routine in vitro functional assays such as proliferation and gene expression pathway analysis in the context of mechanisms of resistance to chemotherapy. In addition, the applicant will also be working with in vivo models to understand the biological role of this pathway in various cancer indications. The successful candidate will have the opportunity to work closely with discovery and development scientists from both academia and industry, and to present his or her work at project team meetings.

Responsibilities will include, but are not limited to, the following:

  • Plan and execute experiments independently
  • Stay current with the literature in order to design experiments that address biological questions
  • Analyze, interpret and present scientific data
  • Interact with drug development team members to design experiments that can address mechanistic questions for the therapeutic of interest
  • Accurately maintain data and reports

    PhD in Pharmacology, Molecular Biology, or a related biological discipline. Expertise in design and execution of cell-based biological studies is required. Experience with rodent model development to characterize anti-cancer activity in vivo, including execution of preclinical pharmacology studies, is required. Experience with grant writing and submission, managing internal and externally conducted studies, and monitoring study conduct and reporting are highly desired. Industry experience is preferred but not essential.

    Skills/Knowledge Required
  • Solid understanding of oncology discovery research, focused primarily on in vitro and in vivo evaluation of small molecules targeting oncology disease targets.
  • Ability to generate high quality data in a dynamic fast paced environment.
  • Excellent written and verbal communication skills
  • Experience in in vivo study conduct; animal handling, husbandry, dosing by multiple routes, observation recording, blood, tissue collection and limited necropsy.
  • Knowledge of in vitro assessment of pharmacologic activity.
  • Knowledge of outsourcing CROs and monitoring of studies at outsourced sites.

    To Apply: Please long onto UC Irvine's AP RECRUIT site:

    Applicants should complete an online application profile and upload the following application materials electronically to be considered for the position:

    1. Curriculum Vitae
    2. Names and Contact Information for 3 References

    The University of California, Irvine is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy.

    To apply, visit





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    Job No:
    Posted: 2/22/2018
    Application Due: 4/23/2018
    Work Type: