RESOURCE TECHNOLOGIST DOWNSTREAM VECTOR
Duties: The Gene Therapy Program (GTP) is entering a new era of unprecedented opportunity with the great potential to reshape the face of medicine as we know it. Our discoveries have set the stage for successful treatments and possibly even cures for devastating genetic diseases.
The laboratory of Dr. Jim Wilson, at GTP of the University of Pennsylvania, has been a leader in the development of innovative vector technology for close to three decades. We have emerged as the 'go-to' organization for public and private partners, who want to participate in the gene therapy space. Currently, we are positioned to lead another round of vector innovation and establish pre-clinical and clinical proof-of-concept in therapeutic applications of in-vivo genome editing.
Our Vector Core is a state-of-the-art facility which provides vector-related materials and services in support of basic and translational research worldwide, producing vectors in support of IND-enabling research, conduct GLP assays, oversee CMO's in vector production and is expanding to conduct state-of-the-art process development.
Due to significant growth, the Vector Core is looking for a new, Resource Technologist C, to support production and purification efforts for clinical AAV vectors.
As a Resource Technologist C, you will be responsible for the production and purification of research grade and GMP-comparable AAV vectors for IND-enabling Pharmacology and Toxicology studies. You will be documenting your activities on batch records for QA review. You will also participate in process optimization and development research activities.
You will work both independently and as part of a team to accomplish project goals within specified timelines. Successful candidates will have a familiarity with upstream and downstream biologics manufacturing, tissue culture, column chromatography and other purification processes.
Qualifications: MS Degree in Biochemical/Chemical Engineering, Biochemistry, Biology, or related disciplines and 3 to 5 years of relevant experience, or an equivalent combination of education and experience, are required.
Must have experience in upstream or downstream biologics manufacturing
Must have experience with tissue culture, column chromatography, or TFF
Must be an independent thinker, meticulous, detail oriented, and analytical
Must be highly motivated, have excellent organizational, communication and interpersonal skills.
Must be able to work independently and as part of a multi-disciplinary team.
Reference Number: 40-27433
Salary Grade: 027
Employment Type: Exempt
Org: DM-Gene Therapy Program
Job Family: I-Technical/Professional Research