Research Assistant Professor_Johnson Lab
Position Type: Permanent Faculty
Department: Pharmacology - 424001
Appointment Type: Fixed Term Faculty
Vacancy ID: FAC0002279
Position Summary: Kinase Inhibitor Synthetic Chemist Supported through a NIH initiative for "Illuminating the Druggable Genome" focused on understudied protein kinases in the human genome, the position involves synthetic/medicinal chemistry approaches to design, synthesize and characterize small molecule inhibitors for a priority list of protein kinases. The position requires the ability to synthesize small organic chemical probes, elucidate mechanisms of action of new small molecule chemical probes, and define the selectivity of the chemical probes for target kinases. Position Functions: 75% Lead organic synthesis and medicinal chemistry efforts to develop structure-activity relationships for small molecule inhibitors and design and synthesize subsequent generations of compounds with specificity for the target kinase of interest. 15% Collaborate with cell biologists, biochemists and pharmacologists to characterize the properties of new kinase-selective chemical probes in living cells. 10% Work with collaborators to develop, write and submit research manuscripts to scientific journals describing the action of chemical probes targeting a priority list of kinases. Use the knowledge gained from the characterization of the small molecule chemical probes developed in the program for submission of new extramurally funded grants.
Education Requirements: Ph.D. in synthetic organic chemistry or medicinal chemistry, or related field.
Qualification and Experience: Extensive experience is required in organic synthesis and medicinal chemistry. Understanding of medicinal chemistry principles to develop structure-activity relationships for small molecule inhibitors and design subsequent generations of compounds with specificity for the target of interest is essential. Excellent verbal and written communication skills are required for collaborative interactions with other members of the research team and for writing scientific papers, research grants, and presentations. A minimum of 1-2 years of postdoctoral research experience in designing and synthesizing small molecule inhibitors of protein kinases is preferred.
Equal Opportunity Employer: The University of North Carolina at Chapel Hill is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or status as a protected veteran.
Department Contact Name and Title: Eileen McElhinney
Department Contact Telephone Number or Email: [email protected]
Special Instructions for Applicants: