RESEARCH SPECIALIST D
Duties: We are seeking a highly motivated and experienced Research Specialist to join our research team and work in the UPENN High-throughput Screening Core (HTSC). The primary mission of the core is to provide the PSOM community with high-throughput screening capabilities to identify genes or organic small molecule modulators of signaling pathways, cellular phenotypes, and protein function in models of human disease.
The successful candidate will be expected to take a leadership role to independently manage high-throughput screening projects in the core. These responsibilities will include the design, optimization, and validation of diverse cell and biochemical assays in high-density formats (i.e. 384 well microtiter plates). These assays will include complex to advanced procedures in molecular biology, protein biochemistry, eukaryotic/mammalian cell biology, use of primary cells, fluorescence microscopy, and high-throughout genetic/chemical screening techniques. A specific focus will be on high-content/phenotypic assay development and creation of computational sequences to analyze data from these assays. He/she must be able to identify and resolve technical problems, and use analytical and decision-making skills to implement projects. The candidate will also be required to execute validated high-throughput chemical and genetic (i.e. siRNA, cDNA) screening experiments, including the operation of laboratory robotics and screening library management. He/she will be responsible for creating computational pipelines to analyze, interpret, and prepare reports of large data sets to be presented to the Scientific and Technical Directors.
The individual will also be required to train and supervise other technical staff in the core and interact with collaborators and scientific staff from laboratories using the core's services to help guide the operations of the core. The candidate must have a proven ability to work in a team environment and excellent communication skills to directly interface with the Directors and users of the core to implement screening projects. Additional responsibilities will include maintaining articulate documentation of daily tasks and maintenance of the laboratory's databases/logs and inventory (i.e. supplies, reagents, safety compliance, and equipment). The applicant should have an advanced understanding of cell biology, molecular biology and biochemistry and direct experience in high-throughput screening.
Qualifications: A minimum of a Master's Degree and 3 years to 5 years of experience or equivalent combination of education and experience required.
Candidates with Master's and Ph. D.'s with direct experience in high-throughput screening and the defined duties will be considered. The ideal candidate will have strong organizational skills, effective communication skills; the ability to work as an effective member of a team, and independently oversee initiation and completion of intermediate to long-range tasks.
Reference Number: 40-27831
Salary Grade: 027
Employment Type: Exempt
Job Family: I-Technical/Professional Research