Oct 15, 2017
Institution Type
Four-Year Institution

Duties: The Gene Therapy Program (GTP) is entering a new era of unprecedented opportunity with the great potential to reshape the face of medicine as we know it. Our discoveries have set the stage for successful treatments and possibly even cures for devastating genetic diseases.

The laboratory of Dr. Jim Wilson, at GTP of the University of Pennsylvania, has been a leader in the development of innovative vector technology for close to three decades. We have emerged as the 'go-to' organization for public and private partners, who want to participate in the gene therapy space. Currently, we are positioned to lead another round of vector innovation and establish pre-clinical and clinical proof-of-concept in therapeutic applications of in-vivo genome editing.

Our Vector Core is a state-of-the-art facility which provides vector-related materials and services in support of basic and translational research worldwide.

The Vector Core is looking to add a Resource Technologist A(RTA) to the GLP Quality Control (QC) group.

As an RTA, you will support IND-enabling studies and human phase I & II clinical trials, conducting and qualifying quality control assays under GLP conditions to determine the quality, quantity, and potency of viral-based vectors while following established protocols or standard operating procedures. You will also participate in technology transfer of new assays to contract manufacturing labs. In this role, you will report to the Associate Director of GLP QC and interact closely with the research QC, assay development and vector manufacturing groups at GTP.

The assays and techniques that are frequently used in genome titer determination, infectivity, biodistribution, in vivo potency assays, endotoxin, purity assays and rcAAV are Mammalian Cell/Tissue Culture, qPCR, cell based potency assays, ELISA, western blots, and gels.

Position is contingent on continued funding.

Qualifications: * Bachelor's of Science in Biology, Biochemistry, Immunology, Virology, or a related field and 1 to 2 years of relevant laboratory experience required
* Mammalian Cell/Tissue culture experience strongly preferred
* Experience conducting qPCR assays is preferred
* Experience conducting non-PCR based assays, such as western analysis and potency assays, is a plus.
* GLP laboratory environment is a plus.
* Ability to work as part of a team
* Excellent oral/written communication skills required

Reference Number: 40-26891

Salary Grade: 024

Employment Type: Exempt

Org: DM-Gene Therapy Program

Special Requirements: Background check required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.

Job Family: I-Technical/Professional Research

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