Senior Applications Chemist

Employer
Quanta BioDesign
Location
Columbus, OH
Posted
Oct 13, 2017
Jobs Outside Higher Education
Other Jobs Outside Higher Education
Institution Type
Outside Academe


Job Description

Although specific roles may vary, the overall goal of a Senior Applications Chemist should be the production and/or process development of dPEG®-biologics and implementing new dPEG® constructs for imaging, therapeutic and bio-assay products. Our scientists should have the desire to learn and to leverage dPEG®-based technology to benefit society. An advanced degree, Ph. D. or M.S. with commensurate experience, in Organic Chemistry is desired. In order to achieve the above goals, the Senior Applications Chemist position contains, but is not limited to, the following expectations:

Knowledge:

-A theoretical and practical knowledge of general chemistry, organic chemistry and biology principles.

-A reasonable understanding of biochemistry and instrumental methods of analysis.

-A theoretical and practical knowledge of organic chemistry principles, including basic functional group transformations and reaction mechanisms.

-An advanced understanding of conjugation chemistry.

-The ability to keep up with scientific developments and utilize scientific databases and journals.

-The ability to design and execute conjugations to targets of interest, based on extant methods.

-The ability to learn and apply new concepts and skills.

Laboratory Skills:

-Work in a manner consistent with Good Laboratory Practices and adhering to Safety, Environmental, and Chemical Hygiene Plans.

-Experience in synthetic organic chemistry

-Experience in conjugation techniques for proteins, peptides, antibodies and antibody fragments

-Working knowledge of development of bio-assays

-Set up and utilize standard laboratory glassware and apparatus for typical functional group transformations.

-Skilled in techniques for isolation and purification of conjugation products, such as size exclusion chromatography, ion exchange chromatography, affinity chromatography, reverse phase and normal phase chromatography.

-Experience with binding assays such as ELISA and SPR to characterize products

-Experience with standard analytical techniques such as thin-layer chromatography, NMR, HPLC, and MS to monitor reactions, optimize reaction conditions, and establish the identity and purity of isolated products.

-Record all procedures and data in electronic laboratory notebooks in a manner sufficient to allow others to reproduce results.

-Analysis and compilation of results to prepare Certificates of Analyses and supporting data packages for products put to stock.

-Assist in the maintenance of laboratory instrumentation and equipment.

Situational Skills:

-Organizing Workflow: Effective time management and the ability to prioritize tasks to meet deadlines and product specifications.

-People Skills: Work collaboratively with scientists to synthesize targets and interpret data, and with the support staff to fill customer orders in a timely manner and maintain training compliance.

-Communication: Effectively communicates plans to QBD colleagues, direct/coordinate/ advise personnel as needed, and report and present experimental findings.

-Problem Solving: Work both independently and collaboratively to develop products, processes, and analytical methods that support the goals of the Quanta BioDesign team

Company Description
Quanta BioDesign is a research and manufacturing company committed to the development of a full range of discrete polyethylene glycol (dPEG®) PEGylation reagents for applications in diagnostics, therapeutics, peptide synthesis, oligonucleotide synthesis, and nanotechnology.

Quanta BioDesign's vision incorporates a dedicated commitment to producing the most useful compounds for current and future applications and needs using synthetic and process technology that allows the most economic incorporation of these products into our customer's applications.


Columbus, OH

7dae09e27

Wed, 27 Sep 2017 08:59:48 PDT

PI99813196