Research Associate- CHO Bioreactor

Clemson, SC
Oct 06, 2017
Institution Type
Four-Year Institution
Clemson University

Location Rhodes Engineering Res Center
Full/Part Time Full-Time
Regular/Temporary Temporary - Grant


Clemson University, University of Delaware, Tulane University, and Delaware State University have joined together to develop new biological approaches to better understand the Chinese hamster ovary (CHO) cell line, which is used to manufacture most biopharmaceuticals.

This project will study the basis for genomic instability in CHO cells to expand a quantitative understanding of the complex interactions between the genome and environment that generates the variable phenotypes. CHO cells provide a unique opportunity to quantitatively address the complex interactions between the genome and phenome, as CHO cells can be cultured in very tightly controlled environments (bioreactors) to generate variable phenomes due to genome instability. The high plasticity of the CHO genome allows for these multiple phenome outcomes, which aids data collection and predictive capacity of these complex interactions.


70% - Essential - Provide technical expertise and leadership in planning, designing, and conducting experiments and analyzing data toward development and optimization of cell culture processes in line with overall project plan and milestones.
•Lead the setup and operation of Sartorius ambr®250 automated bioreactor system
•Direct the processing and analysis of bioreactor samples
•Apply Design of Experiment (DOE) methods for process optimization

20% - Essential - •Maintain substantial knowledge of state-of-the-art principles and theories and contribute to cell culture scientific knowledge base through literature review, conference attendance, and publication.
•Contribute to team meetings, including sub-teams, and project teams

10% - Essential - Be team-focused, results-oriented, science-driven, and embrace the broadening participation values of the EPSCoR Track-2 grant
•Provide supervision to undergraduate and graduate students on the project and be a positive role-model for students as well.


Master's Degree - MS in chemical engineering, biochemistry, microbiology, or related field
Work Exp 1+ years

Experience with lab-scale bioreactors or laboratory automation preferred; Ph.D. in engineering or biological sciences with cell culture process development experience.


• Ph.D. in engineering or biological sciences with cell culture process development experience.
• Prior knowledge in metabolic engineering, protein modulation, and advanced data visualization is desirable.


Standard Hrs: 37.5; Salary is commensurate with experience and credentials.


For full consideration, please submit a cover letter, resume, and three references by December 6, 2017. However, the position will remain open until filled.


Clemson University is an AA/EEO employer and does not discriminate against any person or group on the basis of age, color, disability, gender, pregnancy, national origin, race, religion, sexual orientation, veteran status or genetic information. Clemson University is building a culturally diverse faculty and staff committed to working in a multicultural environment and encourages applications from minorities and women.