University of Colorado - School of Medicine
This position reports directly to the Dr. Richard Davis and is responsible for directing and performing research focused on programmed DNA elimination (chromatin diminution) in nematodes with the goal of understanding the mechanism and function of this unusual form of gene regulation and genome maintenance.
Programmed DNA elimination is a developmental process in which portions of the genome are reproducibly eliminated. This process occurs in diverse eukaryotes ranging from single-celled ciliates, nematodes, and crustaceans to birds and jawless sh (lampreys). In some nematodes, ~15% of the genome is eliminated in the somatic lineages during the 3rd through 5th cleavage (4 to 16 cell stage), while the germline genome remains intact. ~1000 germline and early development expressed genes are eliminated. Chromosomes break, regions are lost, and new and increased numbers of chromosomes are formed. Areas under investigation include analysis in nematodes of 1) how genome regions are marked for retention or elimination, 2) how break regions are identified and the mechanism of chromosome breaks, 3) how eliminated chromosome regions are selectively lost from holocentric chromosomes, and 4) the contributions of epigenetic factors including histone modifications and non-coding RNAs to DNA elimination.
For additional information on the laboratory's research and recent publications, see http://220.127.116.11/Davis_lab/index.html
Candidate is expected to design and carry out independent research, write fellowship applications (if applicable), and publish.
We seek a bright, energetic, motivated individual to contribute to our research program. The candidate will be responsible for carrying out independent experiments. Candidates must be self-motivated, have a strong aptitude for research, and the ability to quickly learn new areas of research and carry out complex experiments. The candidate's primary responsibility will be to conduct independent experiments. Good organizational and computer skills and the ability to work independently as well as part of a research team are necessary.
Successful candidate is expected to be a curious, highly motivated individual, with a positive attitude, and strong interpersonal skills. Post-doctoral fellows are expected to direct independent projects, assist in mentoring junior lab members, and apply for independent fellowship funding.
- PhD degree in Biological Sciences, Chemistry, Biochemistry, Molecular Biology, Genetics, Cell Biology, or a related field within the last three years.
- Record of productivity supported by peer-reviewed publications in internationally recognized English language journals
- Excellent communication skills using the English language.
- Experience in cellular and molecular biology techniques
Applicants with significant experience in at least one or more of the following will be given priority:
- Epigenetics, chromatin, telomeres, and DNA damage/repair
- Use of in vitro DNA damage/repair or telomere systems
- Mitosis, centromeres, or chromosome segregation
- DNA replication timing, chromosome isolation, or higher order chromosome structure analysis
- ChIP and ChIP-seq
- Non-coding RNAs and chromatin
- Immunocytochemistry of nuclei and chromosomes including DNA and/or RNA FISH
- Microinjection or laser microdissection methods
Salary and Benefits:
Salary is commensurate with skills and experience. The University of Colorado offers a full benefits package. Information on University benefits programs, including eligibility, is located at Employee Services.
The University of Colorado Denver is dedicated to ensuring a safe and secure environment for our faculty, staff, students and visitors. To assist in achieving that goal, we conduct background investigations for all prospective employees.
The University of Colorado strongly supports the principle of diversity. We encourage applications from women, ethnic minorities, persons with disabilities and all veterans. The University of Colorado is committed to diversity and equality in education and employment.
The Immigration Reform and Control Act requires that verification of employment eligibility be documented for all new employees by the end of the third day of work. Alternative formats of this ad are available upon request for persons with disabilities.
Application Materials Required:Cover Letter, Resume/CV, List of References
Application Materials Instructions:
Applications are accepted electronically at CU Careers, refer to requisition ID: 10368
When applying, applicants must include:
- A letter of application which specifically addresses the job requirements and outlines qualifications
- A current Resume/CV
- The names, addresses, daytime telephone numbers and e-mail addresses for three professional references, either attached to your resume/CV or uploaded as a separate document
Please do not submit any of your application material (via email) to the job posting contact.
Job Category: Faculty
Primary Location: Aurora
Department: H0001 -- Anschutz Medical Campus - 20085 - SOM-BioChem&Molecular Genetics
Posting Date: Jul 20, 2017
Closing Date: Ongoing
Posting Contact Name: Dick Davis
Posting Contact Email: email@example.com
Position Number: 00736004