Life Science Resesarch Professional 2

Stanford University

Life Science Resesarch Professional 2

Job Number:

Stanford University is seeking a Life Science Research Professional 2 to perform more complex functions and activities involved in defined research projects, and independently conduct a portion of the research project(s).

The Knowles laboratory employs genomic and genetic methods to study the molecular mechanisms that mediate cardiovascular disease risk and pathophysiology, especially insulin resistance. For genes identified through whole genome studies, we work to identify mechanisms by which causal variation is responsible for altered gene structure or function, and employ tissue culture and genetic mouse models to identify how encoded factors participate in the disease process.

The LSRP will perform day-to-day experiments under the guidance of Dr. Knowles, supporting molecular biology, cell culture, and mouse genetic models to accomplish the goals of the lab. This work will require the maintenance and expansion of human tissue culture cell lines and include the preparation of DNA, RNA, and protein from the samples. Maintenance of the animal colony representing a variety of genetic mutations that allow manipulation of causal gene function will also be a critical component of the work to be conducted. S/he will be expected to collect, analyze, and present research data to the research group and make original scientific contributions to the research field. The LSRP may be expected to troubleshoot existing protocols and develop novel protocols and procedures and provide technical and scientific advice to other research personnel in lab. The position will also entail some lab support tasks such as ordering supplies and equipment, maintaining lab records, and adhering to safety regulations.

Duties include:
  • Perform complex (lab and/or field) experiments for a major portion of the research project. Maintain detailed records of experiments and outcomes
  • Interpret and analyze results, often where few guidelines exist. Based on prior results, contribute to development of new research protocols and procedures or adaptation of existing protocols
  • Make recommendations on plan design and/or research direction to principal investigator
  • Work with health and safety department to ensure lab complies with regulations and all required trainings
  • Participate in multidisciplinary teams across different faculties or schools
  • Oversee supply and equipment budget under supervision of principal investigator or business manager
  • Perform ongoing literature review to remain current with new procedures and related research; present findings for lab work group
  • Contribute substantively to the preparation of papers for publication, especially in the results section. May contribute to publication of findings and present ongoing work and findings to colleagues at academic conferences
  • Supervise (either formally or informally) staff or students as needed, including oversight and instruction on techniques, as well as consultation on project work. Serve as technical resource for other research staff
  • Perform general lab maintenance as needed; maintain lab stock, manage chemical inventory and safety records, and provide general lab support as needed. May assist with purchasing laboratory equipment
* - Other duties may also be assigned

  • MS or higher level degree preferred
  • At least 1 year experience
  • Experience with CRISPR, lentivirus genetic techniques
  • Proficiency in mouse colony management including breeding and genotyping
  • Proficiency in scientific writing in English

Bachelor's degree in related scientific field and three years of related experience, or Master's degree, or an equivalent combination of education and relevant work experience.

  • Comprehensive understanding of scientific principles
  • General computer skills and ability to quickly learn and master computer programs, databases, and scientific applications
  • Strong analytical skills and excellent judgment
  • Ability to work under deadlines with general guidance is essential
  • Excellent organizational skills and demonstrated ability to accurately complete detailed work
  • Proficiency with the following techniques required: basic molecular biology techniques such as DNA and RNA purification, PCR, cell transfection and cloning
  • Proficiency in cell culture techniques such as growing and passaging cells
  • Experience and training in handling human cells/blood samples for DNA and RNA purification
  • Experience with database programs for storing and tracking data/samples
  • Prior experience with mouse models of disease
  • Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds
  • Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts
  • Rarely climb, scrub, sweep, mop, chop and mix or operate hand and foot controls
  • Must have correctible vision to perform duties of the job
  • Ability to bend, squat, kneel, stand, reach above shoulder level, and move on hard surfaces for up to eight hours
  • Ability to lift heavy objects weighing up to 50 pounds
  • Ability to work in a dusty, dirty, and odorous environment
  • Position may require repetitive motion
* - Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job.

  • May require working in close proximity to blood borne pathogens
  • May require work in an environment where animals are used for teaching and research
  • Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present
  • Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator
  • May require extended or unusual work hours based on research requirements and business needs

  • Interpersonal Skills: Demonstrates the ability to work well with Stanford colleagues and clients and with external organizations
  • Promote Culture of Safety: Demonstrates commitment to personal responsibility and value for safety; communicates safety concerns; uses and promotes safe behaviors based on training and lessons learned
  • Subject to and expected to comply with all applicable University policies and procedures, including but not limited to the personnel policies and other policies found in the University's Administrative Guide,

Job: Research

Location: School of Medicine
Schedule: Full-time
Classification Level:

To be considered for this position please visit our web site and apply on line at the following link:

Stanford is an equal opportunity employer and all qualified applicants will receive consideration without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, or any other characteristic protected by law.


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