Duties: An established laboratory is seeking a highly motivated and organized senior research investigator. The research interests of our laboratory lie at the intersection of cancer biology, metabolism, tumor micro-environment, inflammation, and metastasis. The lab uses multi-disciplinary approaches, including bioinformatics, cell biology, biochemistry, molecular biology, in vivo animal models of cancer, and primary patient samples to develop a deeper understanding of the influences of oxygen and nutrient availability on tumor initiation, progression, and metastasis. The ideal candidate will be highly self-motivated, enthusiastic, and have excellent organizational and managerial skills. This position offers the opportunity to participate in an innovative research environment, contribute to the activities of a high impact research laboratory, and gain exposure to the collegial research community within the Abramson Family Cancer Research Institute and Abramson Cancer Center. The successful candidate will also supervise and mentor trainees.

Qualified individuals will be expected to oversee general lab operations and assist other lab personnel with experimental procedures and analysis, as well as to develop new projects and assist in grant and manuscript writing. The successful applicant will apply CRISPR/CAS9 genome engineering to generate mutant cell lines and mice, and assess metabolic changes. Additional duties include, but are not limited to, animal surgeries, animal husbandry, DNA preparation, RNA isolation, protein purification and preparation, PCR-based genotyping, RT-PCR, western blotting, molecular sub-cloning, cell culture, immunofluorescence, live cell imaging, cell perfusion and NMR spectroscopy, and spectral analysis.

Qualifications: A PhD in biological sciences, such as cancer biology, genetics, biochemistry, cell biology, or developmental biology is required. In addition, the applicant should have 5 to 7 years of research experience including completed postdoctoral training for at least 4 years duration, with experience applying molecular biology techniques to a cancer biology setting. Experience studying the metabolic effects of the tumor micro-environment on cancer cells and applying approaches such as imaging, CRISPR screens, and mouse models of cancer, is highly desired. A proven ability to analyze large biological data sets using R, MATLAB, etc. is a plus.

Reference Number: 40-26246

Salary Grade: RES

Employment Type: Exempt

Org: CD-CDB Cancer Biology

Special Requirements:

Job Family: I-Technical/Professional Research