Post-Doctoral Fellow

Location
Aurora, CO
Posted
Jul 08, 2017
Position Type
Postdoc
Institution Type
Four-Year Institution



University of Colorado School of Medicine

Anschutz Medical Campus

Department of Pediatrics

Section of Hematology, Oncology, and Bone Marrow Transplantation

Post-Doctoral Fellow/Trainee

Position # 610700 - Requisition # 10202



The University of Colorado Denver Anschutz Medical Campus is a public research university serving more than 18,000 students. We award nearly 4,000 degrees each year, including more graduate and professional degrees than any other Colorado institution. With our solid academic reputation, award-winning faculty and renowned researchers, we offer more than 140 highly rated degree programs through 13 schools and colleges. The university receives over $400 million in research awards each year. In addition to the wide array of health-related programs and facilities offered at CU Anschutz in Aurora, Colo. a significant number of undergraduate and graduate degree programs are taught at CU Denver, our comprehensive campus in the heart of downtown Denver-one of America's most vibrant urban centers. CU Denver is located steps from the Denver Center for Performing Arts and the LoDo District affording our students, faculty and staff access to a broad array of academic, professional, community, recreational and cultural outlets.



The University of Colorado Anschutz Medical Campus ranks among the top institutions nationally in clinical care, education and research. Its 230-acre campus, designed to enhance collaboration and interprofessional education, hosts the College of Nursing; the Schools of Dental Medicine, Medicine, Pharmacy, and Public Health; the Graduate School; a Health Sciences Library; and two hospitals. Strategically located contiguous to the campus are a biosciences research park and the soon-to-be-completed Veterans Hospital. CU Anschutz offers two undergraduate degrees, 35 graduate degrees, and five first-professional programs. More than 4,000 students learn alongside faculty members who also make meaningful medical discoveries and provide expert clinical care through 1.5 million patient-visits annually. A hub for research and innovation, CU Anschutz receives over $400 million in research awards each year and has filed 1,300 patent applications and formed 53 new companies since 2002.



A national leader in health care and life sciences, CU Anschutz is the only comprehensive academic health sciences center in Colorado and the largest in the Rocky Mountain region. Located in Aurora, Colo., it is one of the newest education, research and patient care facilities in the world. With six schools and colleges, CU Anschutz trains the health sciences workforce of the future by blending education, research and clinical care all in one place. This strategic collaboration among diverse health care fields allows knowledge to travel directly from the research bench to the patient's bedside. Read CU Anschutz Quick Facts here.



The University of Colorado Denver, Anschutz Medical Campus is committed to recruiting and supporting a diverse student body, faculty and administrative staff. The university strives to promote a culture of inclusiveness, respect, communication and understanding.



Nature of Work

This position is part of an exciting research program to understand the molecular mechanisms of brain tumor biology. The laboratory uses cellular and mouse models to recapitulate the human disease, with an emphasis on epigenetics in medulloblastoma. We are looking for a PhD scientist who is interested in studying the role of histone modifications in brain tumors using standard molecular biology techniques and genome wide analysis such as ChIP-Seq, and array based expression profiling or RNA-Seq. We are also looking for experience with in vivo models of brain development/disease/tumors. Knowledge of epigenetic regulation and mechanism of gene expression in stem cell specification and differentiation is highly desired.

This position reports directly to Dr. Vibhakar, Associate Professor of Pediatrics and the laboratory PI. This position supervises undergraduate and medical students on summer lab rotations. This position requires the ability to work and collaborate with other laboratory members in the research group.

Scope of Research

100 % effort to studying the role of epigenetic factors that regulate medulloblastoma. Specific project involves studying the role of Histone methylation in response to Myc oncogene activation in medulloblastoma. Specific duties include:
  • Cell culture of tumor cells.
  • Transfection of histone modifying enzymes in to cells.
  • Measuring consequences of Histone modifications by western blotting, qPCR, Chip-Seq and gene expression profiling.
  • Evaluating phenotypic consequences of histone modifications by measuring cell proliferation, cell self-renewal, cell death and senescence using standard cell biology techniques such as flow cytometry, cell culture, and immunohistochemistry.Creating tumors in mice and evaluating the consequences of alternations in histone modifications on tumor development and growth.Set up mouse breeding/genotypying and maintain mouse colonies.
  • Independently performed lab experiments.
  • Collection and analysis of all data.
  • Synthesis of data presenting data at lab meetings, reviewing literature relevant to project and writing of manuscript.
  • Maintain accurate and current laboratory notebook including all experimental details.

PLEASE NOTE: Candidates will be responsible for travel expenses related to the interview process and any relocation expenses, if applicable.

Salary and Benefits:

The hiring salary for this position is $47,476.56. This position is not eligible for overtime compensation.

The University of Colorado offers a full benefits package. Information on University benefits programs, including eligibility, is located at https://www.cu.edu/employee-services.

The University of Colorado Denver Anschutz Medical Campus is dedicated to ensuring a safe and secure environment for our faculty, staff, students and visitors. To assist in achieving that goal, we conduct background investigations for all prospective employees.

The University of Colorado Denver Anschutz Medical Campus is committed to recruiting and supporting a diverse student body, faculty and administrative staff. The university strives to promote a culture of inclusiveness, respect, communication and understanding. We encourage applications from women, ethnic minorities, persons with disabilities and all veterans. The University of Colorado is committed to diversity and equality in education and employment.

The Immigration Reform and Control Act requires that verification of employment eligibility be documented for all new employees by the end of the third day of work. Alternative formats of this ad are available upon request for persons with disabilities.


Qualifications

Minimum Qualifications:

  • Graduation from an accredited university with a PhD in Genetics, Cancer Biology, Biochemistry or Molecular Biology;
  • Minimum of 2 years of Cancer/Molecular Biology lab experience;
  • Excellent communication skills in English;
  • Proven ability to work independently within a research lab;
  • Demonstrates the proficiency in computer software, equipment operation, or research technical skills.


Condition of Employment:

  • Must be willing and able to pass a national criminal background check
  • Required Competencies: Knowledge, Skills, and Abilities:
  • Knowledge and experience with mouse models;
  • Ability to work with mouse models;
  • Knowledge and experience with Cell culture;
  • Knowledge of and experience using Histone modifications by western blotting, qPCR, Chip-Seq and gene expression profiling.


Preferred Qualifications:

  • Prior experience with murine cancer or brain disease models;
  • Experience with stem cell biology and relevant assays (low cytometric analysis and flow sorting of stem or progenitor population)'
  • Prior experience in chromatin biology;
  • Knowledgeable of epigenetic regulation and mechanism of gene expression in stem cell specification.



Special Instructions to Applicants:Application deadline: This posting will remain open until the position has been filled.



Application Materials Required:Cover Letter, Resume/CV, List of References

Application Materials Instructions:

Applications are accepted electronically at CU Careers, refer to requisition ID: 10202

When applying, applicants must include:
  1. A letter of application which specifically addresses the job requirements and outlines qualifications
  2. A current Resume/CV,
  3. The names, addresses, daytime telephone numbers and e-mail addresses for three professional references, either attached to your resume/CV or uploaded as a separate document
Please be advised that the University does check references as part of the employment process.

Please do not submit any of your application material (via email) to the job posting contact.



Job Category: Faculty

Primary Location: Aurora

Department: H0001 -- Anschutz Medical Campus - 20877 - SOM-PEDS Hematology-Onc-GenOps

Schedule: Full-time

Posting Date: Jul 7, 2017

Closing Date: Ongoing

Posting Contact Name: Paul Lopez

Posting Contact Email: Paul.J.Lopez@ucdenver.edu

Position Number: 00610700

PI98565199