Jun 08, 2017
Institution Type
Four-Year Institution

Stanford University


Job Number:

The Department of Comparative Medicine at Stanford University is seeking a Life Science Research Professional 3 (Research Histotechnologist) to join our active histology lab, the Comparative Medicine Animal Histology Service Center (CMAHSC). The lab provides high-quality histotechnological support for many Stanford investigators, involving a wide diversity of tissue types needing expertise in staining, immunohistochemistry, and cryotomy. The lab operates under the auspices of the Stanford University's Shared Scientific Facilities Management System.

About the Department of Comparative Medicine

The Department of Comparative Medicine in the School of Medicine is an academic department whose faculty teach at the undergraduate, graduate, professional and post graduate levels. The Department's faculty are also engaged in collaborative and comparative research, with animal model expertise and programs in veterinary pathology, pain and anesthesia, rodent reproductive biology, infectious disease, cancer, bioengineering and neuroscience. Our mission is to advance human and animal health through outstanding research, veterinary care and training.

For more information about the department visit http://med.stanford.edu/compmed.html

About the Position

The Life Science Research Professional 3 (Research Histotechnologist) will independently process tissues both for histological staining, immunohistochemistry, large tissue blocks, and advanced chemical stains. S/he will perform highly complex research testing, including extremely complex manual assays. S/he will function as an expert technical resource independently performing all technical aspects of histology slide preparation, including the most complex assays, and will provide training and mentorship to other staff and clients. Histology/histopathology slides prepared in this lab are used for both veterinary diagnostic and animal model research support.

Duties include:

  • Design approaches for all aspects of operating a research histology laboratory, including background research, histotechnology execution, problem-solving, and preparing slides for use in publications and other scientific venues.
  • Serve as an expert technical resource for multidisciplinary teams across different faculties or schools. Provide consultation for researchers working with novel systems or tissues (e.g. cell cultures or organoids), provide original ideas of major methodologies, and contribute to manuscript and grant preparation.
  • Work independently to process tissues both standard and more complex histological protocols including tissue blocking, chemical processing, embedding, sectioning 3-10 micron frozen and paraffin-embedded blocks, and histochemical (special), assays, evaluate results, and take corrective action as needed.
  • Independently perform immunohistochemistry, using a variety of commercially, and newly developed monoclonal and polyclonal antibodies, links and chromogens, and consult with veterinary pathologists to troubleshoot and optimize staining results on FFPE and frozen tissues.
  • Evaluate, validate, and optimize new histochemical and immunohistochemical assays; may develop new staining techniques, evaluate new technologies and make recommendations on new acquisitions and/or upgrades of instrumentation and software.
  • Section large, non-standard sized paraffin blocks and frozen tissue embedded in OCT on cryostat.
  • Interpret results often where few guidelines exist. Based on prior results, contribute to development of new research protocols and procedures or adaptation of existing protocols. Make recommendations on plan design and/or research direction to principal investigator.
  • Contribute substantively to the preparation of papers for publication, especially in the results section. May contribute to publication of findings and present ongoing work and findings to colleagues at academic conferences.
  • Maintain an awareness of emerging new instrumentation and techniques in histotechnology through literature review and professional meetings.
  • Prepare periodic progress reports or written reports on all phases of the laboratory operations.
  • Review quality assurance and quality control data and take corrective action for assigned area, as needed.
  • Work with health and safety department to ensure lab complies with regulations and all required trainings. Manage chemical inventory and safety records. Maintain documentation and assure that regulatory requirements are met.
  • Maintain detailed documentation of the tests requested and services provided through the iLab platform. Maintain detailed documentation of experiments and outcomes, and techniques followed.
  • Oversee supply and equipment budget under limited supervision of principal investigator or business manager.
  • Supervise and train new staff or students as needed, including hiring, performance management, and related duties, in addition to instruction on techniques and consultation on project work.
* - Other duties may also be assigned Required Qualifications:
  • Minimum of 10 years in research histopathology
  • ASCP certification
  • Working with diverse animal tissue samples for specialized processing
  • Experience as a consultant in preparing grant applications and scientific manuscripts involving research pathology
  • Familiarity with principles and preparation of paraffin embedding, sectioning, and staining animal fixed tissues.
  • Familiarity with principles and preparation of diverse special stains including, but not limited to: silver, trichrome, PAS, B&B, AFB, LFB-HE, Giemsa, and other stains highlighting cellular, tissue, and matrical components.
  • Ability to independently perform immunohistochemistry, using a variety of commercially, and newly developed monoclonal and polyclonal antibodies, links and chromogens, and consult with veterinary pathologists to troubleshoot and optimize staining results on FFPE and frozen tissues.
  • Familiarity with principles and preparation of cryosections of frozen animal tissues.
  • Familiarity with principles of obtaining and preparing positive and negative histological control samples.
  • Advanced understanding of complex testing processes and underlying biology of the system.
  • Ability to independently interpret and synthesize results, from a wide variety of tests, correctly and quickly; and involve others at the appropriate time.
  • Excellent oral and written communication skills in English.
  • Ability to train and educate a wide audience, including staff, postdocs, students and clients
Desired Qualifications:
Expertise in performing high quality IHC, manual processing and cutting oversized paraffin blocks, and experience working with laboratory animal tissues. ASCP qualification in immunohistochemistry (QIHC) is desired, as is extensive experience in performing, validating, and trouble-shooting immunohistochemical techniques. Supervisory experience, and strong computer/data base skills are also desirable.

Education & Experience (Required):

Bachelor's degree in related scientific field and six years of related experience, or advanced degree and four years of related experience

Knowledge, Skills, and Abilities (Required):

  • Comprehensive understanding of scientific principles.
  • Expert level knowledge and skills in field of histotechnology related to research project.
  • General computer skills, experience with databases.
  • Strong analytical skills and excellent judgment.
  • Ability to work under deadlines with general guidance is essential.
  • Excellent organizational skills and demonstrated ability to complete detailed work accurately.
  • Strong project management skills.
Certifications and Licenses:

ASCP certification with qualification in immunohistochemistry (QIHC) is highly desired

Physical Requirements*:
  • Posses full color vision.
  • Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds.
  • Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts.
  • Rarely climb, scrub, sweep, mop, chop and mix or operate hand and foot controls.
  • Must have correctible vision to perform duties of the job.
  • Ability to bend, squat, kneel, stand, reach above shoulder level, and move on hard surfaces for up to eight hours.
  • Ability to lift heavy objects weighing up to 50 pounds.
  • Ability to work in a dusty, dirty, and odorous environment.
  • Position may require repetitive motion.
* - Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job.

Working Conditions:
  • High pressure, and busy environment.
  • Work under extreme time constraints.
  • May work with or around radiation or electromagnetic fields, lasers and allergens/chemicals.
  • May require working in close proximity to blood borne pathogens.
  • May require work in an environment where animals are used for teaching and research.
  • Position may at times require the employee to work with or be in areas where hazardous materials are present.
  • Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator.
  • May require extended or unusual work hours based on research requirements and business needs.
Working Standards (from JDL):
  • Interpersonal Skills: Demonstrates the ability to work well with Stanford colleagues and clients and with external organizations.
  • Promote Culture of Safety: Demonstrates commitment to personal responsibility and value for safety; communicates safety concerns; uses and promotes safe behaviors based on training and lessons learned.
  • Subject to and expected to comply with all applicable University policies and procedures, including but not limited to the personnel policies and other policies found in the University's Administrative Guide, http://adminguide.stanford.edu.

Job: Research

Location: School of Medicine
Schedule: Full-time
Classification Level:

To be considered for this position please visit our web site and apply on line at the following link: stanfordcareers.stanford.edu

Stanford is an equal opportunity employer and all qualified applicants will receive consideration without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, or any other characteristic protected by law.


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