Postdoctoral Associate - Biochemistry
The Kladde lab at the UF Health Cancer Center in the Department of Biochemistry and Molecular Biology is currently accepting applications for a Postdoctoral Associate. The lab investigates mechanisms of epigenetic dysregulation in cancer, focusing on establishment and maintenance of epigenetic gene silencing during cancer progression.
Duties will include:
Determining the molecular basis of epigenetic changes during progression of breast and colon cancer in the genomes of cultured cells and patient-derived tumors.
Development of innovative, single-molecule epigenetic assays of DNA methylation and chromatin structure; analysis of protein-DNA interactions in vitro and in vivo, e.g., by chromatin immunoprecipitation (ChIP); and genome editing by CRISPR/Cas9 to test the functional relevance of regulatory sequences.
Researching, interpreting, and critically evaluating primary literature; compiling and analysis of data; and maintaining a complete, accurate, and up-to-date lab notebook.
Preparing and editing manuscripts for publication for dissemination of results as well as applications for grants and patents in consultation with the supervisor.
Supervising and training of graduate students (PhD and Master's level), undergraduates, and student workers.
PhD or an MD/PhD degree in the fields of biochemistry, molecular biology, or a related discipline. Applicants should have excellent communication and problem-solving skills and the ability to work flexible hours depending on specific experiments.
Experience in protein biochemistry (e.g., nucleosome reconstitution and/or protein overexpression) or epigenomics (e.g., ChIP-seq, RNA-seq, bisulfite sequencing, bioinformatics).
Special Instructions to Applicants:
Upload a Curriculum Vitae, the names of three references (or three letters of recommendation), and a cover letter explaining your specific interest in joining the lab and obtaining training.
This position has been reposted. Previous applicants need not reapply.
This posting is for two available positions.
Health Assessment Required: No