Research Associate

Charlottesville, VA
May 09, 2017
Institution Type
Four-Year Institution

Working Title: Research Associate

Position Type: Professional Research Staff

Department: Department of Biochemistry and Molecular Genetics

Location: Charlottesville

Posting Date: 01-06-2017

Posting Summary:
The Department of Biochemistry and Molecular Genetics at the University of Virginia is seeking an experimental biologist research associate in the laboratory of Francine Garrett-Bakelman, M.D., Ph.D., to study epigenetic mechanisms of disease in cancer. The expected start date is April 17, 2017 (start date is flexible).

The focus of the Garrett-Bakelman Lab is to understand how epigenetic mechanisms contribute to disease pathogenesis in Acute Myeloid Leukemia (AML). Research in the lab utilizes human patient samples in addition to using murine models and tumor cell lines to perform a variety of functional and genome scale technologies. These include but are not limited to cell-based assays, DNA cytosine modification assays, RNA-sequencing and chromatin function assays to address fundamental questions about cancer biology and transcriptional regulation (e.g. PMID: 27322744). Projects will be conducted in collaboration with computational biologists and include the identification of epigenetically regulated factors that contribute to the establishment and progression of AML, and characterization of candidate genes using in vitro, ex vivo, and in vivo systems.

Qualified applicants must have a PhD in a life science field and/or an MD degree by the appointment start date. A strong background in molecular and cellular biology and biochemistry, and publications in peer-reviewed journals, are also required. Experience with hematopoiesis/leukemia models and/or primary human patient samples, and a background in next generation sequencing techniques and/or transcriptional regulation, is desirable, but not necessary.

Duties will include design and performance of experiments exploring the basic processes of cell proliferation, gene expression or cancer progression. Experiments require a working knowledge of techniques commonly used in molecular biology and cell biology. The selected candidate will have additional responsibilities of meeting weekly with the Principal Investigator to discuss experimental design and results, conduct literature searches, present results in weekly lab meetings, interdepartmental seminars and at conferences. The candidate is expected to work independently and ethically, document all research data appropriately, assist graduate students and other staff in the lab, apply for independent funding where applicable, and publish data in qualified journals.

To apply, visit and search on Posting Number 0620153. Attach a cover letter, curriculum vitae, a single page description of research experience and interests, and contact information for research work-related reference(s). Applicants will be considered until the position is filled and the start date is flexible; however, for priority consideration, all materials must be received by February 15, 2017.

The University of Virginia is an equal opportunity and affirmative action employer. Women, minorities, veterans, and persons with disabilities are encouraged to apply.

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