Post-Doctoral Research Associate

Charlottesville, VA
May 09, 2017
Institution Type
Four-Year Institution

Working Title: Post-Doctoral Research Associate

Position Type: Professional Research Staff

Department: Department of Molecular Phys and Biological Physics

Location: Charlottesville

Posting Date: 05-09-2017

Posting Summary:
A Post-Doctoral Research Associate is needed in the laboratory of Wladek Minor in the Department of Molecular Physiology and Biological Physics at the University of Virginia. The successful applicant will perform high-profile, NIH-funded research in the area of structural biology and bioinformatics. He or she will work on the development of methods that will lead to faster and more robust structure determination and refinement. He or she will be involved in development of databases and knowledge systems by performing cutting-edge structural biology research for an NIH Integrated Resource for Reproducibility in Macromolecular Crystallography and other high profile projects.

A PhD degree (or the equivalent) in Biology, Biochemistry or Physics with Biophysics background (or similar field) is required. Experience in protein crystallography and excellent knowledge of issues related to protein production/purification, crystallographic data reduction, structure solution and refinement, as documented by at least 10 Protein Data Bank deposits and at least 8 protein crystallography and/or bioinformatics publications, is also required. Experience with HKL-2000 is required, and experience with HKL-3000 is highly desired. Experience with in vitro biochemical screening assays (enzyme kinetics, isothermal titration calorimetry, fluorescence-based thermal shift assays, etc.) is a definite plus. Excellent knowledge of Python, Perl, PHP or other scripting languages; C, C++ or similar compiled languages; and at least 1 year of experience in SQL database programming are essential.

List of Duties:
1) Perform research in the area of structural biology and bioinformatics, including development of methods for faster and more robust structure determination and structure refinement.
2) Work on issues related to Integrated Resource for Reproducibility in Macromolecular Crystallography
3) Use the databases and structure determination tools developed in the laboratory in day-to-day work.
4) Determinations of "stubborn" protein structures, and if possible, identify how the databases and tools can be improved to better address these cutting-edge cases.
5) Help in creation of dynamic reports as required by the Protein Structure Initiative, the EFI and the CSGID.
6) Perform other cutting-edge level research as applicable in the Minor laboratory.

To apply visit and search for posting # 0620929. Complete a candidate profile and submit a CV, cover letter, and contact information for 3 professional references. Questions about the position can be directed to Wladek Minor (

The University of Virginia is an equal opportunity and affirmative action employer. Women, minorities, veterans, and persons with disabilities are encouraged to apply.

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