Research Associate I
GENERAL SUMMARY OF POSITION: Under the direction of the Principal Investigator or designee, the Research Associate I performs a variety of complex research experiments. Major Responsibilities include:
- Prepare samples for TEM and take and analyze images for lab members.
- Work with researchers on the design, preparation, execution and analysis of electron microscopy experiments for TEM, with potential for SEM, and cryo-TEM techniques.
- Acquire and process biological specimens using tissue extraction, sectioning, and chemical fixation techniques.
- Carry out immunocytochemical labeling of tissues and cell cultures using monoclonal and polyclonal antibodies by pre-embedding and post-embedding methods.
- Prepare specimens using cryogenic techniques such high pressure freezing for the preservation of cellular ultrastructure and membrane morphology.
- Keep up with technical advances in specimen preparation by reading primary literature and microscopy web sites.
- Reconstruct electron microscopy data sets (serial sections, tomograms etc).
- Responsible for basic image analysis, e.g. image averaging, filtering, alignment, quantitative analysis
- Perform complex laboratory experiments
- Conduct in-depth analysis of research experiments
- Interpret data, form conclusions, and decide on and plan the next experiments to be done with a high degree of independence
- Write standard operating procedures, schedule work, analyze data, maintain accurate records, and write reports
- Compile and analyze data. Perform computations using image analysis software, spreadsheets, graphing, and curve fitting software
- May modify protocols and be responsible for a single, independent research project
- May assist with budget and/or operational aspects of grant and contract proposals
- Assist in writing the text of scientific publications and grants. Review literature
- Train new laboratory personnel, students, and collaborators
- Comply with all safety and infection control standards
- Perform other duties as required.
- Bachelor's degree in the Biological Sciences, or equivalent experience
- 3 years of relevant research experience
- Knowledge of Microsoft Office products
- Strong ability to analyze complex visual data in a quantitative and objective manner
- Judgment and action skills required to solve commonly encountered problems
- Electron Microscopy Experience