Research Associate I

Location
Worcester, MA
Posted
May 08, 2017
Institution Type
Four-Year Institution
GENERAL SUMMARY OF POSITION:

Under the direction of the Principal Investigator or designee, the Research Associate I performs a variety of complex research experiments.

Major Responsibilities include:

  • Prepare samples for TEM and take and analyze images for lab members.
  • Work with researchers on the design, preparation, execution and analysis of electron microscopy experiments for TEM, with potential for SEM, and cryo-TEM techniques.
  • Acquire and process biological specimens using tissue extraction, sectioning, and chemical fixation techniques.
  • Carry out immunocytochemical labeling of tissues and cell cultures using monoclonal and polyclonal antibodies by pre-embedding and post-embedding methods.
  • Prepare specimens using cryogenic techniques such high pressure freezing for the preservation of cellular ultrastructure and membrane morphology.
  • Keep up with technical advances in specimen preparation by reading primary literature and microscopy web sites.
  • Reconstruct electron microscopy data sets (serial sections, tomograms etc).
  • Responsible for basic image analysis, e.g. image averaging, filtering, alignment, quantitative analysis
MAJOR RESPONSIBILITIES:

  • Perform complex laboratory experiments
  • Conduct in-depth analysis of research experiments
  • Interpret data, form conclusions, and decide on and plan the next experiments to be done with a high degree of independence
  • Write standard operating procedures, schedule work, analyze data, maintain accurate records, and write reports
  • Compile and analyze data. Perform computations using image analysis software, spreadsheets, graphing, and curve fitting software
  • May modify protocols and be responsible for a single, independent research project
  • May assist with budget and/or operational aspects of grant and contract proposals
  • Assist in writing the text of scientific publications and grants. Review literature
  • Train new laboratory personnel, students, and collaborators
  • Comply with all safety and infection control standards
  • Perform other duties as required.



REQUIRED QUALIFICATIONS:

  • Bachelor's degree in the Biological Sciences, or equivalent experience
  • 3 years of relevant research experience
  • Knowledge of Microsoft Office products
  • Strong ability to analyze complex visual data in a quantitative and objective manner
  • Judgment and action skills required to solve commonly encountered problems
PREFERRED QUALIFICATIONS:

  • Electron Microscopy Experience
SUPERVISION RECEIVED:

Under the direction of the Principal Investigator, or designee

SUPERVISION EXERCISED:

May functionally supervise aides, technicians, and associates

ENVIRONMENTAL WORKING CONDITIONS:

Wet chemistry laboratory, and may require appropriate contact with biohazards, radionuclides, toxins, animals, and human specimens.

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