Job description

Duties: The Director of Bioinformatics (DB) oversee and handle all aspects of bioinformatics research at the Gene Therapy Program(GTP) at PENN.

GTP is a complex R&D organization consisting of research laboratories supported by multiple core functions which provide internal capacity to perform gene transfer studies from basic research through phase 1 proof-of-concept human trials. We currently employ 150FTEs with an annual operating budget $50M. The R&D enterprise has at its core a translational infrastructure that includes: technology discovery, specialized immunology assays operating under Good Laboratory Practices (GLP), a Vector Core and Manufacturing unit that conducts Good Manufacturing Practices (GMP)-based assays and oversees CMOs in vector production, and a large non-clinical program for animal testing under GLP, including nonhuman primate and mouse vivaria; GTP collaborates with the Department of Medicine in the organization and conduct of phase 1 trials. In addition to these translational programs, GTP is involved in an ambitious vector discovery program called AAV 3.0 which is being leveraged against standard gene replacement therapy programs, as well as research in genome editing. These programs involve multiple federal, nonprofit and commercial partners.

Virtually all aspects of the R&D efforts involve modern day tools of molecular and cellular biology which require extensive computational analysis of the data. We are in need of extensive support in terms of bioinformatics. The DB will be asked to build a bioinformatics program to support GTP's R&D efforts as well as being responsible for hands-on analysis work. He/she will have available the necessary equipment to build out the program, however he/she may need to build a larger team as the computational tools become more accessible to the scientists.

A successful candidate for the DB role should have hands on experience with Next Generation Sequencing analysis as well as have knowledge of genome editing and virus genomes.

Qualifications: The minimum of a Master's degree and 5 years to 7 years of experience or equivalent combination of education and experience required.
* Extensive knowledge of life science research in both academic and bio-pharmaceutical settings
* Proven track record of accomplishment in bioinformatics especially as it relates to evaluation of deep sequencing RNA and DNA data
Ability to work with computer scientists in the development of novel computational tools for life science research
Self starter but also a strong desire to contribute and work collaboratively to achieve goals
Success in roles requiring execution of multiple tasks while responding to multiple priorities
Highly functioning, detail-oriented, and analytical candidate who can think strategically
Excellent oral/written communication skills required

Reference Number: 40-25643

Salary Grade: 030

Employment Type: Exempt

Org: DM-Gene Therapy Program

Special Requirements: Background check required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.

Job Family: B-Executive/Managerial Administration




Diversity Profile: University



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Job No:
Posted: 4/23/2017
Application Due: 4/23/2018
Work Type: