SENIOR RESEARCH INVESTIGATOR
Duties: The Sr. Research Investigator will work within the Immune Regulation Laboratory on an outstanding project examining the cellular and molecular phenotype, pathogenic role, and functional interactions of regulatory T cells and myeloid-derived suppressor cells in canine cancer or autoimmune disease (according to your expertise). The lab proposes to extend its previous research in the area of peripheral tolerance in canine cancer and canine autoimmune disease, with the aim of advancing it into the clinical arena to develop novel immune therapies. Emphasis is on One Health, One Medicine, using spontaneous canine disease for both its veterinary importance and its unique ability to model equivalent human diseases. Work will also require the use of murine models.
Qualifications: PhD in Immunological Sciences or equivalent doctoral degree and at least 3 to 5 years of experience or equivalent combination of education and experience recurred. Five plus years of experience preferred.
Must be an enthusiastic, driven individual who has strong experience and skills in protein analysis (multicolor flow cytometry, Western blot, immunohistochemistry / immunofluorescence, ELISA), primary cell culture, molecular biology (cloning, mutagenesis, transcriptional analysis, isolation of mRNA and its analysis, plasmid and lentivirus preparation and gene transfer), and animal work. A veterinary qualification is not a pre-requisite.
Willingness to receive clinical samples for immunophenotyping by flow cytometry and research purposes, involving evening and weekend work as needed. Computer literacy, including the ability to use a variety of software packages to analyze data.
Must have a strong publication track record. Must possess strong communication and team-playing skills, a detail-oriented mind-set, and the ability to work independently in a collaborative setting.
Reference Number: 58-25602
Salary Grade: RES
Employment Type: Exempt
Org: Clinical Studies-Philadelphia
Special Requirements: Background check required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.
Job Family: I-Technical/Professional Research