PRA/Histotechnologist or Histotechnician

Aurora, CO
Apr 19, 2017
Institution Type
Four-Year Institution

University of Colorado - School of Medicine

Professional Research Assistant

Nature of Work:

The Professional Research Assistant / Histotechnologist or Histotechnician position is offered through the (Medicine) Division of Medical Oncology within a cancer/molecular biology secured research laboratory located in Aurora, Colorado USA. The position will not be involved in course instruction and is not eligible for tenure.

Duties and Responsibilities:

The PRA / Histo position will be responsible for the oversight and management of tissue and cells from multiple research projects under the direction and guidance of the PI in the research laboratory of Dr. Antonio Jimeno. The position has the opportunity to complete the following laboratory duties:
  • Prepare histological sections and the develop immunohistochemistry protocols on tissue samples for preclinical and clinical research involving human and non-human research.
  • Analyze and interpret established endpoints using direct microscopy and digital computer systems.
  • Perform RNA, DNA extraction from fresh and fixed tissues
  • PRA will also be responsible for independent design of experiments, validation of endpoints, assessment and quality control, assessment and purchasing of equipment, training of junior PRA and post-doctoral fellows in IHC and tissue-related techniques, coordinating with outside vendors, and coordinating with outside sponsors for tissue and technique exchanges.
  • Work with PI to fulfill government and private grant obligations including publications and presentations. The successful candidate interacts on a regular basis with principal investigators, research study coordinators, post-doctoral fellows, and other laboratory personnel.
  • In collaboration with the PI, apply independent thought regarding research project decisions that may alter research objectives and direction. Contribute to writing peer reviewed manuscripts and grants.
  • Fiscal responsibility: use of University procurement card for research laboratory travel/membership and lab supply needs and monitor and report on the program budget monthly.

Supervision Received:

This position reports to the principal investigator of the laboratory, Antonio Jimeno, MD, PhD, and to the research faculty (Drs Stephen Keysar PhD and Jason Morton PhD).

Examples of Work Performed:

The PRA/ histotechnologist will be responsible for the following: specimen collection, grossing, processing, embedding, sectioning and staining of research material for H&E and immunohistochemistry. Position will be responsible for new protocol development including single and multi-staining IHC, immunofluorescence (including multiplexing techniques) and laser microdissection on both paraffin and frozen tissue samples for pre-clinical and clinical research involving human and non-human samples. Other lab duties include: interpretation and scoring of H&E and immunohistochemistry in a research setting. Preparation and handling of tissue microarrays from tumor and cell line pellets is also required. Knowledge of staining platforms including Dako Autostainer, Aperio Imaging, and Arcturus micro laser dissection is preferred.

The work will also include processing, managing, archiving and analyzing tumor and normal tissue samples originating from human and mouse anticancer drug clinical trials and archival samples. The histotechnologist/histotechnician will be responsible for RNA, DNA extraction from fresh and fixed tissue samples and independent design of experiments, validation of endpoints, assessment and quality control.

The PRA will maintain lab protocol notebook, format figures for grants and talks, be responsive to time-sensitive requests associated with manuscripts, grants, and meetings, and be flexible and helpful. Finalist must be able to prepare and maintain regulatory documentation determined by study requirements, state, and federal law. Participation in internal and external audits and GCP/GLP regulatory training, understanding of protocols for clinical trial tissue management, and expertise in legal and regulatory contract management with sponsors is required. Regular updates to the PI and additional investigators will be required on a weekly basis.

The successful candidate will be responsible for the assessment and purchasing of equipment, supplies required for daily laboratory operations, coordinating with outside vendors and sponsors for tissue and technique exchanges. Finalist will ensure all necessary laboratory compliance requirements are met (Environmental health and Safety, DEA and others if necessary).

The successful candidate will be also responsible for coordinating with outside clinical trial sponsors for tissue management from clinical trial patients as well as coordinating with Pathology Department at UCSOM for tissue bank construction and management.

The research assistant will participate in team research meetings, weekly individual supervision, complete all necessary research recordkeeping and documentation. No supervisory responsibilities. The research assistant willingly accepts additional responsibilities and duties as assigned by management and performs other related duties and procedures, including special projects, as directed.

Working Conditions:

The position requires 100% effort working with the secured research laboratory. The position will require research laboratory bench work skills, moderate lifting of research laboratory supplies, and good hand to eye coordination.

Salary and Benefits:

The starting salary range will be at the low $40's commensurate with skills and experience. The University of Colorado offers a full benefits package. Information on University benefits programs, including eligibility, is located at Employee Services.

The University of Colorado Denver is dedicated to ensuring a safe and secure environment for our faculty, staff, students and visitors. To assist in achieving that goal, we conduct background investigations for all prospective employees.

The University of Colorado strongly supports the principle of diversity. We encourage applications from women, ethnic minorities, persons with disabilities and all veterans. The University of Colorado is committed to diversity and equality in education and employment.

The Immigration Reform and Control Act requires that verification of employment eligibility be documented for all new employees by the end of the third day of work. Alternative formats of this ad are available upon request for persons with disabilities.


Minimum Qualifications:

The minimum requirements for this PRA / Histotechnologist or Histotechnician requires all of the following items shown on your CV/Resume to be considered in the applicant pool:

  • Bachelor's degree education in appropriate scientific field (Biology/Chemistry/biochemistry or applicable related sciences;
  • 3+ years of previous research experience including IHC and antibody protocol development.
  • Prior experience with computers is required. Prior experience with databases is required. Team-oriented and flexible.

Preferred Qualifications:

  • HTL (preferred), QIHC certification preferred
  • Experience working with diverse populations in an academic setting or within a higher education environment.
  • Three years of laboratory experience using the above research laboratory techniques.
  • Strong computer skills proficient with MS Office software include basic accounting.
  • The final candidate will be motivated, reliable and willing to learn new research techniques, able to communicate and collaborate; must possess ability to work independently and effectively with research details.

Special Instructions to Applicants:

Only all complete applicant data (attaching histo certficate copy) will be reviewed by the University search committee.

The review of applications will start immediately and will be accepted until the position is filled, but full consideration will be given to complete applications.

Application Materials Required:Cover Letter, Resume/CV, List of References, Reference Letters (Not Confidential), Additional Attachments - Refer to Application Materials Instructions Below

Application Materials Instructions:

Applications are accepted electronically at CU Careers, refer to requisition ID: 9197

When applying, applicants must include:
  1. A letter of application which specifically addresses the job requirements and outlines qualifications
  2. A current Resume/CV
  3. The names, addresses, daytime telephone numbers and e-mail addresses for three professional references, either attached to your resume/CV or uploaded as a separate document
  4. Attach the proof Histology certificate, HRL or QIHC preferred
Please be advised that the University does check references as part of the employment process.

Please do not submit any of your application material (via email) to the job posting contact.

Job Category: Faculty

Primary Location: Aurora

Department: H0001 -- Anschutz Medical Campus - 20214 - SOM-MED-Oncology

Schedule: Full-time

Posting Date: Apr 18, 2017

Closing Date: Ongoing

Posting Contact Name: Everlyn Sandoval

Posting Contact Email:

Position Number: 00626170


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